Blood carnitine status after orthotopic liver transplantation in patients with end-stage liver disease.
Blood carnitine status after orthotopic liver transplantation in patients with end-stage liver disease.
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DOI：
10.1093/ajcn/50.3.504
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发表时间：
1989-09
期刊：
影响因子：
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通讯作者：
J. Palombo;P. Borum;R. Jenkins;C. Trey;B. Bistrian
中科院分区：
文献类型：
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作者：
J. Palombo;P. Borum;R. Jenkins;C. Trey;B. Bistrian
我们确定了原位肝移植对终末期肝病患者血浆和红细胞肉碱浓度的影响。移植前，血浆和红细胞肉毒碱显着高于正常水平。分配因子（红细胞肉碱与血浆肉碱的比率）是我们参考人群中观察到的四倍。肝置换后，血浆和红细胞肉碱在 6 个月内达到正常水平。然而，当时的分配系数仍然很高。这些结果表明：1）根据血浆和红细胞中的肉碱浓度，没有证据表明严重肝病患者存在肉碱缺乏；2）血浆和红细胞之间肉碱分配的改变在肝置换后持续大于或等于 6 个月。
We determined the effects of orthotopic liver transplantation on plasma and red cell carnitine concentrations in patients with end-stage liver disease. Before transplantation, plasma and red cell carnitine were significantly elevated above normal. The partitioning factor (ratio of red cell carnitine to plasma carnitine) was four times greater than that observed in our reference population. After hepatic replacement, plasma and red cell carnitine approached normal levels within 6 mo. The partitioning factor, however, remained elevated at that time. These results indicate that 1) there is no evidence for carnitine deficiency in severe liver disease on the basis of carnitine concentrations in the plasma and red compartments and 2) altered partitioning of carnitine between plasma and red cells persists for greater than or equal to 6 mo after hepatic replacement.