Cortisol as a Biomarker of Alcohol Use in Combat Veterans: A Literature Review and Framework for Future Research.
Cortisol as a Biomarker of Alcohol Use in Combat Veterans: A Literature Review and Framework for Future Research.
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皮质醇作为退伍军人饮酒的生物标志物：文献综述和未来研究框架。
DOI：
10.1080/15504263.2020.1771504
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发表时间：
2020
影响因子：
2.2
通讯作者：
Zambrano-Vazquez,Laura
中科院分区：
文献类型：
--
作者：
Szabo,YvetteZ;Breeding,Tessa;Hejl,Christina;Guleria,RakeshwarS;Nelson,StevenM;Zambrano-Vazquez,Laura
目的酒精使用和酒精使用障碍(AUD)在退伍军人中日益受到关注，特别是那些最近在伊拉克和阿富汗发生冲突的退伍军人。对酒精使用和AUD的生物标记物的研究已经转向加强对AUDS的发展和维持的理解，以及调查其与临床严重性和潜在的治疗反应预测因素的关系。皮质醇是一种被称为应激激素的糖皮质激素，它与压力和创伤以及增加酒精抑制效果有关。方法/结果本文综述了现有文献，并对未来的研究提出了建议，以评估皮质醇是否可能是退伍军人酒精使用障碍风险的生物标志物。具体地说，战斗部署和高水平创伤后应激障碍，再加上重返社会的压力，可能会扰乱皮质醇，增加澳门氏症的风险。也可能有双向的影响，如酒精被用作一种应对机制，可以失调下丘脑-垂体-肾上腺(HPA)轴功能和皮质醇。结论在这一框架下，皮质醇可能作为AUD发生的生物标志物，以及风险或复发的生物标志物。这篇综述总结了理论和临床意义，并对未来的研究方向进行了展望。
ObjectiveAlcohol use and alcohol use disorders (AUDs) are an increasing concern among veterans, particularly those from recent conflicts in Iraq and Afghanistan. The study of biomarkers in alcohol use and AUD has moved to enhancing the understanding of the development and maintenance of AUDs, as well as investigating its association with clinical severity and potential predictors of treatment response. Cortisol, a glucocorticoid known as a stress hormone, has been linked with both stress and trauma, as well as increased alcohol suppression effects.Method/ResultsThe present review summarizes existing literature and presents suggestions for future research to evaluate whether cortisol may be a possible biomarker of alcohol use disorder risk in combat veterans. Specifically, aspects of combat deployments and high levels of PTSD, coupled with the stress of reintegration may dysregulate cortisol and increase risk to AUD. There may also be bidirectional impacts, such that alcohol is used as a coping mechanism and can dysregulate hypothalamic pituitary adrenal (HPA) axis functioning and cortisol.ConclusionsIn the context of this framework, cortisol may serve as a biomarker for the development of AUD, as well as a biomarker of risk or relapse. This review ends with both theoretical and clinical implications, as well as directions for future research.