Constitutive expression of the SlP1 receptor in adult tissues
Constitutive expression of the SlP1 receptor in adult tissues
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DOI：
10.1016/j.prostaglandins.2004.01.006
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发表时间：
2004-01-01
影响因子：
2.9
通讯作者：
Hla, T
中科院分区：
文献类型：
--
作者：
Chae, SS;Proia, RL;Hla, T
S1 P（1）（也称为EDG-1）是生物活性脂质鞘氨醇-1-磷酸（S1 P）的G蛋白偶联受体。内皮细胞中S1 P（1）受体的激活可诱导多种细胞效应，包括细胞增殖、存活、迁移和形态发生。最近的体内研究表明，S1 P（1）受体是发育过程中血管成熟所必需的。虽然许多研究报道了S1 P（1）在血管系统中的功能作用以及S1 P（1）转录本在各种小鼠器官中的存在，但S1 P（1）的组织分布尚未完全确定。在这项研究中，我们通过β-半乳糖苷酶报告基因的表达来确定S1 P（1）的表达模式，该报告基因被敲入S1 P（1）焦点。我们发现S1 P（1）在成年小鼠组织的各种细胞类型中广泛表达，表明该受体在血管和非血管组织的许多生理过程中起调节作用。(C)2004年爱思唯尔公司All rights reserved.
S1P(1) (also known as EDG-1) is a G-protein coupled receptor for the bioactive lipid, sphingosine-1-phosphate (S1P). Activation of S1P(1) receptor in endothelial cells induces diverse cellular effects, including cell proliferation, survival, migration and morphogenesis. Recent in vivo studies showed that the S1P(1) receptor is required in vascular maturation during development. While a number of studies reported a functional role of S1P(1) in vascular system and the presence of S1P(1) transcripts in various mouse organs, tissue distribution of S1P(1) has not been fully defined. In this study, we determined the expression pattern of S1P(1) by beta-galactosidase reporter gene expression, which is knocked into the S1P(1) focus. We show that S1P(1) is widely expressed in various cell types of adult mouse tissues, suggesting a regulatory role of this receptor in numerous physiological processes in both vascular and non-vascular tissues. (C) 2004 Elsevier Inc. All rights reserved.