Modification of pentobarbital effects by natural and synthetic polypeptides: dissociation of brain and pituitary effects.
Modification of pentobarbital effects by natural and synthetic polypeptides: dissociation of brain and pituitary effects.
复制标题
天然和合成多肽对戊巴比妥效应的修饰：脑和垂体效应的解离。
DOI：
10.1016/0024-3205(75)90300-8
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发表时间：
1975
期刊：
影响因子：
6.1
通讯作者：
P. Loosen
中科院分区：
文献类型：
--
作者：
A. Prange;G. Breese;G. Jahnke;B. Martin;B. Cooper;J. Cott;I. Wilson;L. Alltop;M. Lipton;G. Bissette;C. Nemeroff;P. Loosen
促甲状腺激素释放激素（TRH）拮抗戊巴比妥镇静和低温；促生长激素释放抑制因子放大了它们。其他下丘脑多肽释放因子、P物质及多种氨基酸均无效。TRH的三个同系物拮抗戊巴比妥；一个人放大了它。同类药物作为戊巴比妥拮抗剂的效力与其作为垂体促甲状腺激素释放剂的效力无关。
Thyrotropin releasing hormone (TRH) antagonizes pentobarbital sedation and hypothermia; somatotropin release inhibiting factor amplifies them. Other hypothalamic polypeptide releasing factors, Substance P and a variety of amino acids are ineffective. Three congeners of TRH antagonize pentobarbital; one amplifies it. The potencies of congeners as pentobarbital antagonists are unrelated to their potencies as pituitary thyrotropin releasers.