Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action
Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action
复制标题
玄黄连乙醇提取物通过抗炎作用预防实验性糖尿病肾损伤
DOI：
10.1677/joe-08-0481
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发表时间：
2009-03-01
影响因子：
4
通讯作者：
Zhang, Xun
中科院分区：
文献类型：
--
作者：
He, Li Juan;Liang, Min;Zhang, Xun
有证据表明，炎症过程参与糖尿病肾病的发展和/或进展。然而，糖尿病患者肾脏炎症的有效治疗实际上是未知的。胡黄连（Picrorhiza scrophulariiflora，PS）的根茎是一种长期用于治疗炎症性疾病的传统药物。本研究的目的是验证PS（EPS）的乙醇提取物可以减轻糖尿病肾病患者炎症的假设。将链脲佐菌素诱导的糖尿病大鼠随机分为两组，分别灌胃EPS或溶媒。同时对一组非糖尿病对照大鼠进行处理。与溶剂处理的糖尿病大鼠相比，EPS处理的动物显示肾巨噬细胞浸润和趋化因子（C-C基序）配体2（CCL 2）和TGFB 1的过表达显著减少。这与早期糖尿病肾病的结构和功能异常（如肾小球肥大）的减弱有关。系膜扩张和蛋白尿。EPS的施用显著减少了NADPH氧化酶依赖性的过氧化物生成，并降低了糖尿病肾脏中丙二醛和晚期氧化蛋白产物的表达。这些数据表明，EPS可能：改善糖尿病肾病，可能通过抑制氧化还原敏感性炎症。
There is evidence that inflammatory processes are involved in the development and/or progression of diabetic nephropathy. However, effective treatment for inflammation in the kidneys of diabetic is practically unknown. The rhizomes of Picrorhiza scrophulariiflora (PS) are a traditional medication long used to treat inflammatory diseases. The aim of the present study was to test the hypothesis that the ethanol extract of PS (EPS) may reduce inflammation in patients with diabetic kidneys. Streptozotocin-induced diabetic rats were randomly assigned to two groups treated with a gavage of either EPS or vehicle. A group of non-diabetic control rats was treated concurrently. Compared with vehicle-treated diabetic rats, EPS-treated animals displayed a significant decrease in renal macrophage infiltration and overexpression of chemokine (C-C motif) ligand 2 (CCL2) and TGFB1. This was associated with attenuation of the Structural and functional abnormalities of early diabetic nephropathy, such as glomerular hypertrophy.. mesangial expansion, and albuminuria. Administration of EPS Significantly reduced NADPH oxidase-dependent,it peroxide generation and decreased expression of malondialdehyde and advanced oxidation protein products ill diabetic kidney. These data Suggest that EPS might: improve diabetic nephropathy, probably through inhibition of redox-sensitive inflammation.