Innate versus adaptive immunity in Candida albicans infection
Innate versus adaptive immunity in Candida albicans infection
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DOI：
10.1046/j.0818-9641.2004.01217.x
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发表时间：
2004-04-01
影响因子：
4
通讯作者：
Clancy, RL
中科院分区：
文献类型：
--
作者：
Ashman, RB;Farah, CS;Clancy, RL
白色念珠菌是一种常见的机会致病菌，可引起浅表感染和全身感染。临床观察表明，皮肤粘膜感染通常与细胞介导的免疫反应缺陷有关，而全身感染更常见于中性粒细胞数量或功能缺陷的患者。对小鼠模型中宿主抵抗胃肠道和口腔感染的机制的分析表明，尽管清除也涉及吞噬细胞，但其绝对依赖于CD4（+）T细胞。 IL-12 和 TNF-α 似乎都是重要的介质，但小鼠品系依赖性的感染易感性变化可能与 T 细胞增强骨髓吞噬细胞的产生有关。在小鼠全身感染中，先天反应和适应性反应的作用尚不明确。对免疫缺陷和 T 细胞耗尽的小鼠的研究表明，酵母菌的清除可能主要是先天反应的功能，而适应性反应可能会限制组织损伤或有可能引起免疫病理学，具体取决于感染发生的宿主遗传背景。
Candida albicans is a common opportunistic pathogen, causing both superficial and systemic infection. Clinical observations indicate that mucocutaneous infections are commonly associated with defective cell-mediated immune responses, whereas systemic infection is more frequently seen in patients with deficiencies in neutrophil number or function. Analysis of mechanisms of host resistance against gastrointestinal and oral infection in mouse models has demonstrated an absolute dependence on CD4(+) T cells, although clearance also involves phagocytic cells. Both IL-12 and TNF-alpha appear to be important mediators, but mouse strain-dependent variations in susceptibility to infection may be related to T-cell enhancement of production of phagocytic cells by the bone marrow. In murine systemic infection, the role of innate and adaptive responses is less well defined. Studies in immunodeficient and T-cell-depleted mice suggest that clearance of the yeast may be predominantly a function of the innate response, whereas the adaptive response may either limit tissue damage or have the potential to cause immunopathology, depending on the host genetic context in which the infection takes place.