OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy
OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy
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DOI：
10.3928/23258160-20190703-04
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发表时间：
2019-07-01
影响因子：
1
通讯作者：
Pavesio, Carlos
中科院分区：
文献类型：
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作者：
Furino, Claudio;Shalchi, Zaid;Pavesio, Carlos
背景与目的：描述不同阶段的急性后部多灶性片状色素上皮病（APMPPE.PATIENTS和METHODS）的视网膜和脉络膜表现：通过眼底生物显微镜进行回顾性、非比较性病例系列研究。结果：3例6眼双侧APMPPE患者均行眼底自发荧光（FAF）、荧光素血管造影（FA）、吲哚菁绿色血管造影（ICGA）、频域光学相干断层扫描（SD-OCT）和扫频源OCT血管造影（SS-OCTA）检查。FAF显示多灶性、分支状高自发荧光斑块伴低自发荧光区域; FA显示早期低荧光，伴晚期高荧光; ICCA显示早期和晚期低荧光。SD-OCT成像显示双侧视网膜变薄，外界膜（ELM）破裂，感光器-视网膜色素上皮复合体严重改变。SS-OCTA显示病例1和病例2的脉络膜毛细血管内有广泛的多发性暗斑。稀疏和空隙的血管纹理中也检测到深丛，不像在案件3，病变较小，早期，表明视网膜血管可能会受到影响后choriocapillaris objectives.CONCLUSIONS：APMPPE可能会导致从一个独特的局灶性缺血choriocapillaris，和OCTA允许作者准确定位所有的斑块状病变和监测领域的缺席液体信号。
BACKGROUND AND OBJECTIVE: To describe retinal and choroidal findings in different stages of acute posterior multifocal placoid pigment epitheliopathy (APMPPE).PATIENTS AND METHODS: Retrospective, noncomparative case series studied by fundus biomicroscopy. fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain optical coherence tomographic (SD-OCT), and swept-source OCT angiography (SS-OCTA).RESULTS: Six eyes of three patients with bilateral APMPPE were included. FAF showed multifocal, branched patches of hyperautolluorescence with areas of hypoautofluorescence; FA disclosed early hypofluorescence, with late-phase hyperfluorescence; ICCA showed early and late-phase hypofluoresconce. SD-OCT imaging revealed bilateral retinal thinning, external limiting membrane (ELM) disruption, and severe alteration of the photoreceptor-retinal pigment epithelium complex. SS-OCTA showed widespread multiple dark spots in the choriocapillaris in Cases 1 and 2. Rarefaction and voids in the vascular texture were also detected in the deep plexus, unlike in Case 3, where the lesions were smaller and earlier, suggesting that retina vasculature may be affected after the choriocapillaris obstruction.CONCLUSIONS: APMPPE may result from a distinct focal ischemia in the choriocapillaris, and OCTA allowed the authors to localize exactly all the placoid lesions and monitor the areas of absent fluid signal.