The prognostic value of microvascular invasion in early-intermediate stage hepatocelluar carcinoma: a propensity score matching analysis.
The prognostic value of microvascular invasion in early-intermediate stage hepatocelluar carcinoma: a propensity score matching analysis.
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DOI：
10.1186/s12885-018-4196-x
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发表时间：
2018-03-12
期刊：
影响因子：
3.8
通讯作者：
Lu C
中科院分区：
文献类型：
--
作者：
Shen J;Wen J;Li C;Wen T;Yan L;Li B;Yang J;Lu C
微血管浸润（MVI）是肝细胞癌（HCC）的一个负性预后因素。然而，其在巴塞罗那临床肝癌（BCLC）分期的不同亚组中的预后价值仍有待阐明。回顾性分析了458例MVI阴性和204例MVI阳性的肝切除患者。经过倾向评分匹配（PSM）分析，产生了187对匹配的患者。长期生存率采用Kaplan-Meier法进行比较。MVI患者通常有更晚期的肿瘤。术后MVI患者生存率明显低于无MVI患者（P < 0.001）。在亚组分析中，在PSM前后，BCLC A期HCC患者无MVI的预后优于MVI患者（p < 0.001和p = 0.024）。对于BCLC B期HCC，PSM前未行MVI的患者的长期生存率明显更好（p = 0.001）。然而，PSM后两组的总生存率（OS）相当（p = 0.682），尽管MV I阳性组的复发率更高（p = 0.011）。手术类型、卫星病灶、肿瘤大小和血清ALT水平是与MV I阳性组生存率相关的统计学显著因素。肿瘤数目、肿瘤大小和中性粒细胞/淋巴细胞比率（NLR）是预测MVI阴性组生存的因素。其在BCLC不同分期亚组中的预后价值不同。MVI是BCLC A期患者预后的独立预测因子。对于BCLC B期HCC，MV I阳性组通过更晚期的HCC预后差。
Microvascular invasion (MVI) is well established as a negative prognostic factor for hepatocelluar carcinoma (HCC). However, its prognostic value in different subgroups of Barcelona Clinical Liver Cancer (BCLC) stages remains to be elucidated. Four hundred fifty-eight MVI-negative and 204 MVI-positive patients who underwent hepatectomy were retrospectively analyzed. After propensity score matching (PSM) analysis, 187 pairs of matched patients were generated. Long-term survival was compared by the Kaplan–Meier method. Patients with MVI commonly had more advanced tumors. All the patients with MVI had significantly worse survival rate compared to the patients without MVI before and after PSM(p < 0.001). In the subgroup analysis, BCLC stage A HCC patients without MVI had better prognosis than those with MVI before and after PSM (p < 0.001 and p = 0.024). For BCLC stage B HCCs, long-term survival was significantly better for patients without MVI before PSM(p = 0.001). However, the overall survival (OS) rate was comparable between both groups after PSM (p = 0.682), although MVI-positive group had a higher rate of recurrence (p = 0.011).. Surgery type, satellite lesions, tumor size, and serum ALT level were statistically significant factors associated with survival in MVI-positive group. Tumor number, tumor size and neutrophil to lymphocyte ratio (NLR) were predictors of survival in MVI-negative group. Its prognostic value in different subgroups of BCLC stages differed. MVI is an independent predictor of prognosis in patients with BCLC stage A. For BCLC stage B HCCs, MVI-positive group had poor prognosis through more advanced HCCs.
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无大血管侵犯的单发性肝细胞癌根治性切除术后早期和晚期肝内复发的危险因素。
影响因子：
--
作者：
Li, Shu-Hong;Guo, Zhi-Xing;Guo, Rong-Ping
通讯作者：
Guo, Rong-Ping
影响因子：
3.4
作者：
Codony, C.;Lopez-Ben, S.;Figueras, J.
通讯作者：
Figueras, J.
DOI：
10.1002/hep.27877
发表时间：
2015-09
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Banerjee S;Wang DS;Kim HJ;Sirlin CB;Chan MG;Korn RL;Rutman AM;Siripongsakun S;Lu D;Imanbayev G;Kuo MD
通讯作者：
Kuo MD
影响因子：
13.5
作者：
Fuks, David;Dokmak, Safi;Belghiti, Jacques
通讯作者：
Belghiti, Jacques
影响因子：
3.2
作者：
Hung, Hung-Hsu;Lei, Hao-Jan;Wu, Jaw-Ching
通讯作者：
Wu, Jaw-Ching