Receptor tyrosine kinases endocytosis in endothelium: biology and signaling.
Receptor tyrosine kinases endocytosis in endothelium: biology and signaling.
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DOI：
10.1161/atvbaha.114.303217
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Simons M
中科院分区：
文献类型：
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作者：
Zhang X;Simons M
受体酪氨酸激酶（receptor tyrosine kinases，RTKs）参与调节内皮细胞增殖、迁移和血管生成等重要生物学过程。现在普遍认为RTK信号发生在细胞内以及质膜上，尽管许多重要的细节仍有待解决。内吞作用和随后的细胞内运输时空调节RTK信号传导，而“信号传导内体”为信号传导事件的区室化提供平台。本文以血管内皮生长因子受体-2为范例，总结了我们对内皮细胞RTK胞吞作用和信号传导的最新研究进展。
Receptor tyrosine kinases (RTKs) are involved in regulation of key process in roles in endothelial biology including proliferation, migration and angiogenesis. It is now generally accepted that RTK signaling occurs intracellularly as well as on the plasma membrane although many important details remain to be worked out. Endocytosis and subsequent intracellular trafficking spatiotemporally regulate RTK signaling while “signaling endosomes” provide a platform for the compartmentalization of signaling events. This review summarizes recent advances in our understanding of endothelial RTK endocytosis and signaling using vascular endothelial growth factor receptor-2 as a paradigm.