SIGNIFICANCE OF IGM ANTIBODY TO HEPATITIS-C VIRUS IN PATIENTS WITH CHRONIC HEPATITIS-C
SIGNIFICANCE OF IGM ANTIBODY TO HEPATITIS-C VIRUS IN PATIENTS WITH CHRONIC HEPATITIS-C
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DOI：
10.1002/hep.1840150604
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发表时间：
1992-06-01
期刊：
影响因子：
13.5
通讯作者：
BARBARA, L
中科院分区：
文献类型：
--
作者：
BRILLANTI, S;MASCI, C;BARBARA, L
我们评估了慢性丙型肝炎病毒感染患者血清丙型肝炎病毒IgM抗体阳性与肝病活动性之间的相关性。 血清样本取自10名血清ALT水平正常的丙型肝炎病毒抗体阳性无症状患者，14名未经治疗的临床和组织学证实的慢性丙型肝炎患者，以及26名临床和组织学证实的慢性丙型肝炎患者，这些患者被分配接受重组干扰素α-2a（600万IU，每周三次，持续6个月）。 采用酶联免疫吸附试验检测血清标本中丙型肝炎病毒相关C100-3抗原IgM抗体。 观察患者至少12个月。所有10例ALT值正常的患者丙型肝炎病毒IgM抗体检测阴性。 而慢性丙型肝炎患者中33例（82%）血清抗-HCV IgM抗体阳性，且ALT水平与抗-HCV IgM抗体水平呈正相关（r = 0.803，p < 0.001）。在干扰素治疗期间，26例治疗患者中有18例（69%）ALT水平降至正常范围，8例（31%）停止治疗后保持正常。 在未经治疗的患者中，在对干扰素治疗无应答的治疗患者中以及在复发的应答患者中，在研究期间未观察到丙型肝炎病毒IgM抗体水平的显著变化。 与此相反，IgM抗体丙型肝炎病毒成为不可检测的干扰素治疗结束时，在7个8例患者的持续respons.In结论，我们发现血清IgM抗体丙型肝炎病毒的存在和丙型肝炎引起的肝脏疾病的活动之间呈正相关。 在对α-干扰素治疗有反应的慢性丙型肝炎患者中，丙型肝炎病毒IgM抗体的消失预示着反应将持续。
We assessed the correlation between the positivity for serum IgM antibody to hepatitis C virus and the activity of liver disease in patients with chronic hepatitis C virus infection. Serum samples were taken from 10 antibody to hepatitis C virus-positive asymptomatic patients with normal serum ALT levels, from 14 untreated patients with clinically and histologically proven chronic hepatitis C and from 26 patients with clinically and histologically proven chronic hepatitis C assigned to receive recombinant interferon alpha-2a (6 million IU three times a week for 6 mo). Each serum specimen was tested for IgM antibody to hepatitis C virus-associated C100-3 antigen by enzyme-linked immunosorbent assay. Patients were observed for at least 12 mo.All 10 patients with normal ALT values tested negative for IgM antibody to hepatitis C virus. In contrast, 33 of 40 (82%) patients with chronic hepatitis C had IgM antibody to hepatitis C virus, and a positive correlation was seen between the ALT level and the level of IgM antibody to hepatitis C virus (r = 0.803, p < 0.001).During interferon treatment, ALT levels declined into the normal range in 18 of 26 treated patients (69%) and remained normal after stopping treatment in 8 patients (31%). In untreated patients, in treated patients who did not respond to interferon treatment and in responder patients who relapsed, no significant changes in IgM antibody to hepatitis C virus levels were seen during the study period. In contrast, IgM antibody to hepatitis C virus became undetectable by the end of interferon treatment in seven of eight patients with a sustained response.In conclusion, we found a positive correlation between the presence of serum IgM antibody to hepatitis C virus and the activity of the hepatitis C-induced liver disease. In patients with chronic hepatitis C showing a response to alpha-interferon treatment, the disappearance of IgM antibody to hepatitis C virus predicted that the response would be sustained.