NOT THAT RIGID MIDGETS AND NOT SO FLEXIBLE GIANTS: ON THE ABUNDANCE AND ROLES OF INTRINSIC DISORDER IN SHORT AND LONG PROTEINS
NOT THAT RIGID MIDGETS AND NOT SO FLEXIBLE GIANTS: ON THE ABUNDANCE AND ROLES OF INTRINSIC DISORDER IN SHORT AND LONG PROTEINS
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DOI：
10.1142/s0218339012400086
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发表时间：
2012-12-01
影响因子：
1.6
通讯作者：
Uversky, Vladimir N.
中科院分区：
文献类型：
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作者：
Howell, Mark;Green, Ryan;Uversky, Vladimir N.
在自然界中，蛋白质内部的无序或具有无序区域的蛋白质是非常常见的。这些蛋白质具有许多生物学功能，与传统有序蛋白质的生物学活性互补。发现编码长和短无序区域的氨基酸序列存在显著差异，这种差异被用于开发内源性疾病的长度依赖性预测因子。在这项研究中，我们分析了真核蛋白质内在无序的缩放，并研究了长度依赖性功能的存在，归因于蛋白质含有长无序区域。
Intrinsically disordered proteins or proteins with disordered regions are very common in nature. These proteins have numerous biological functions which are complementary to the biological activities of traditional ordered proteins. A noticeable difference in the amino acid sequences encoding long and short disordered regions was found and this difference was used in the development of length-dependent predictors of intrinsic disorder. In this study, we analyze the scaling of intrinsic disorder in eukaryotic proteins and investigate the presence of length-dependent functions attributed to proteins containing long disordered regions.