The sensitivity of acyclovir-resistant mutants of herpes simplex virus to other antiviral drugs.
The sensitivity of acyclovir-resistant mutants of herpes simplex virus to other antiviral drugs.
复制标题
单纯疱疹病毒阿昔洛韦耐药突变体对其他抗病毒药物的敏感性。
DOI：
10.1093/infdis/143.2.281
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Graham Darby
中科院分区：
文献类型：
--
作者：
Hugh J. Field;Andrew McMillan;Graham Darby
本文研究了三种来源于单纯疱疹病毒（HSV）1株的无环鸟苷（ACV）耐药突变株，以确定它们对9种抗HSV药物的耐药范围。其中两个突变体是胸苷激酶缺陷型（TK-），并且对通常由HSV TK磷酸化的药物具有抗性。另一种突变体诱导正常水平的TK;由于TK+病毒似乎更可能在体内繁殖良好，因此特别令人感兴趣。这种突变体被“TK介导的”药物抑制：已经在使用的碘尿苷和两种具有临床潜力的药物，1-β-阿拉伯呋喃糖基胸腺嘧啶和E-5-（2-溴乙烯基）-2 '-脱氧尿苷。所有突变体对三氟胸苷和9-β-D-阿拉伯呋喃糖基腺嘌呤敏感。这些结果表明，在体外HSV株的交叉耐药性的研究将有助于在有效的化疗中使用的替代药物的调查。
Three acyclovir (ACV)-resistant mutants derived from a strain of herpes simplex virus (HSV) type 1 were studied to determine the range of their resistance to nine drugs active against HSV. Two of the mutants were thymidine kinase-deficient (TK-) and were resistant to drugs that are usually phosphorylated by HSV TK. The other mutant induced normal levels of TK; it was of special interest since TK+ viruses appear more likely to multiply well in vivo. This mutant was inhibited by "TK-mediated" drugs: idoxuridine, which is already in use, and two drugs with promising clinical potential, 1-beta-arabinofuranosylthymine and E-5-(2-bromovinyl)-2'-deoxyuridine. All of the mutants were sensitive to trifluorothymidine and 9-beta-D-arabinofuranosyladenine. These results suggest that the study of cross-resistance of HSV strains in vitro will aid in the investigation of alternative drugs for use in effective chemotherapy.