Selective estrogen receptor modulators and phytoestrogens.
Selective estrogen receptor modulators and phytoestrogens.
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选择性雌激素受体调节剂和植物雌激素。
DOI：
10.1055/s-0028-1088304
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发表时间：
2008-10
期刊：
影响因子：
2.7
通讯作者：
Jordan VC
中科院分区：
文献类型：
--
作者：
Oseni T;Patel R;Pyle J;Jordan VC
过去二十年的科学成就使乳腺癌的治疗和预防发生了革命性的变化。这主要是因为有针对性的治疗，以及对雌激素及其受体与乳腺癌之间的关系有了更好的理解。这些发现之一是使用合成的选择性雌激素调节剂(SERM)，如他莫昔芬，用于雌激素受体(ER)阳性乳腺癌的治疗策略。由于这一进步，数十万人的生命得到了拯救。他莫昔芬不仅用于乳腺癌患者的治疗策略，也用于高危绝经前妇女的预防。另一种合成的SERM，雷洛昔芬，最初用于预防骨质疏松症，在预防高危绝经后妇女方面也与他莫昔芬一样有效。在世界某些地区，特别是在亚洲，乳腺癌的发病率很低。这些女性的饮食中豆类含量高，脂肪含量低，这与西方饮食非常不同。对大豆衍生物保护作用的兴趣导致了植物雌激素的研究，一些人将大豆的代谢产物描述为天然的SERM。因此，许多临床问题被提出，即植物雌激素是否可以预防乳腺癌。植物雌激素也存在于其他天然食物中。本文综述了更常见的SERM，他莫昔芬和雷洛昔芬的发展和作用。此外，本文还将重点介绍植物雌激素及其与SERM的相似性的最新研究。
Scientific achievements in the last two decades have revolutionized the treatment and prevention of breast cancer. This is mainly because of targeted therapies and a better understanding of the relationship between estrogen, its receptor, and breast cancer. One of these discoveries is the use of synthetic selective estrogen modulators (SERMs) such as tamoxifen in the treatment strategy for estrogen receptor (ER) positive breast cancer. Hundreds of thousands of lives have been saved because of this advance. Not only is tamoxifen used in the treatment strategy for patients who have breast cancer, but also for prevention in high risk premenopausal women. Another synthetic SERM, raloxifene, which was initially used to prevent osteoporosis, is also as effective as tamoxifen for prevention in high risk postmenopausal women. In certain regions of the world, particularly in Asia, a low incidence of breast cancer has been observed. These women have diets that are high in soy and low in fat, much unlike the western diet. Interest in the protective effects of soy derivatives has led to the research of phytoestrogens, metabolites of soy that are described by some as natural SERMs. As a result, many clinical questions have been raised as to whether phytoestrogens, which are also found in other natural foods, can protect against breast cancer. This article reviews the development and role of the more common SERMs, tamoxifen and raloxifene. In addition, this paper will also highlight the emerging studies on phytoestrogens and their similarity to SERMs.
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DOI：
10.1001/jama.1923.02650100027012
发表时间：
1923-07-01
影响因子：
--
作者：
Allen, E;Doisy, EA
通讯作者：
Doisy, EA
DOI：
10.1073/pnas.90.7.2690
发表时间：
1993-04-01
影响因子：
11.1
作者：
FOTSIS, T;PEPPER, M;SCHWEIGERER, L
通讯作者：
SCHWEIGERER, L
影响因子：
120.7
作者：
Cummings, SR;Eckert, S;Jordan, VC
通讯作者：
Jordan, VC
影响因子：
4.8
作者：
Chang, Edmund C.;Frasor, Jonna;Katzenellenbogen, Benita S.
通讯作者：
Katzenellenbogen, Benita S.
影响因子：
7.3
作者：
ALLEN, KE;CLARK, ER;JORDAN, VC
通讯作者：
JORDAN, VC