Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder.
Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder.
复制标题
共病双相情感障碍和物质使用障碍的执行和视觉记忆功能障碍更大。
DOI：
10.1016/j.psychres.2012.06.013
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发表时间：
2012
影响因子：
11.3
通讯作者：
Langenecker,ScottA
中科院分区：
文献类型：
--
作者：
Marshall,DavidF;Walker,SaraJ;Ryan,KellyA;Kamali,Masoud;Saunders,ErikaFH;Weldon,AnneL;Adams,KennethM;McInnis,MelvinG;Langenecker,ScottA
双相情感障碍（BD）中认知功能障碍的测量已经确定了状态和特质依赖性指标。物质滥用（SUD）对BD的影响已被提出。本研究调查了有或无SUD病史的双相情感障碍患者的潜在差异性、叠加性或交互性认知功能障碍。200五十六人与BD，98没有SUD和158与SUD，和97健康对照（HC）完成诊断访谈，神经心理学测试，和症状严重程度量表。BD组在大多数认知因素上表现出比HC组更差的表现。BD与SUD表现出显着较差的性能比BD没有SUD的视觉记忆和概念推理/集转移。此外，物质使用与抑郁症状在听觉记忆和情绪加工方面存在显著的交互作用。有SUD病史的BD患者表现出更差的视觉记忆和概念推理能力，超出了在无SUD的BD患者中观察到的这些领域的功能障碍，这表明对整合，完形驱动的处理领域的影响更大。未来的研究可能会解决纵向结果作为BD，SUD，并结合BD/SUD的功能，以评估神经系统参与这些疾病的风险和影响。
Measures of cognitive dysfunction in Bipolar Disorder (BD) have identified state and trait dependent metrics. An influence of substance abuse (SUD) on BD has been suggested. This study investigates potential differential, additive, or interactive cognitive dysfunction in bipolar patients with or without a history of SUD. Two hundred fifty-six individuals with BD, 98 without SUD and 158 with SUD, and 97 Healthy Controls (HC) completed diagnostic interviews, neuropsychological testing, and symptom severity scales. The BD groups exhibited poorer performance than the HC group on most cognitive factors. The BD with SUD exhibited significantly poorer performance than BD without SUD in visual memory and conceptual reasoning/set-shifting. In addition, a significant interaction effect between substance use and depressive symptoms was found for auditory memory and emotion processing. BD patients with a history of SUD demonstrated worse visual memory and conceptual reasoning skills above and beyond the dysfunction observed in these domains among individuals with BD without SUD, suggesting greater impact on integrative, gestalt-driven processing domains. Future research might address longitudinal outcome as a function of BD, SUD, and combined BD/SUD to evaluate neural systems involved in risk for, and effects of, these illnesses.