Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure
Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure
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DOI：
10.1152/jappl.2001.90.6.2341
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发表时间：
2001-06-01
影响因子：
3.3
通讯作者：
Singh, MAF
中科院分区：
文献类型：
--
作者：
Pu, CT;Johnson, MT;Singh, MAF
慢性心力衰竭（CHF）的特点是骨骼肌肌病，目前的治疗模式或有氧运动无法最佳解决。将 16 名患有 CHF 的老年女性与 80 名没有 CHF 的同龄女性进行比较，并随机接受为期 10 周的渐进阻力训练或控制伸展运动。患有 CHF 的女性的肌肉力量明显较低 (P < 0.0001)，但有氧能力与未患 CHF 的女性相当。运动训练耐受性良好，CHF 患者的静息心脏指数没有变化。阻力训练者的力量平均提高了 43.4 +/- 8.8%，对照组为 -1.7 +/- 2.8% (P = 0.001)，肌肉耐力平均提高了 299 +/- 66%，对比 1 +/- 3% (P = 0.001)，6 分钟步行距离平均提高了 49 +/- 14 m (13%)，对比 -3 +/- 19 m (-3%) (P = 0.03)。骨骼肌中 I 型纤维面积 (9.5 +/- 16%) 和柠檬酸合酶活性 (35 +/- 21%) 的增加可独立预测 6 分钟步行距离的改善 (r(2) = 0.78；P = 0.0024）。高强度渐进式阻力训练可改善患有慢性心力衰竭的老年女性受损的骨骼肌特征和整体运动表现。这些收益很大程度上是由骨骼肌而不是静息心脏适应来解释的。
Chronic heart failure (CHF) is characterized by a skeletal muscle myopathy not optimally addressed by current treatment paradigms or aerobic exercise. Sixteen older women with CHF were compared with 80 age-matched peers without CHF and randomized to progressive resistance training or control stretching exercises for 10 wk. Women with CHF had significantly lower muscle strength (P < 0.0001) but comparable aerobic capacity to women without CHF. Exercise training was well tolerated and resulted in no changes in resting cardiac indexes in CHF patients. Strength improved by an average of 43.4 +/- 8.8% in resistance trainers vs. -1.7 +/- 2.8% in controls (P = 0.001), muscle endurance by 299 +/- 66% vs. 1 +/- 3% (P = 0.001), and 6-min walk distance by 49 +/- 14 m (13%) vs. -3 +/- 19 m (-3%) (P = 0.03). Increases in type I fiber area (9.5 +/- 16%) and citrate synthase activity (35 +/- 21%) in skeletal muscle were independently predictive of improved 6-min walk distance (r(2) = 0.78; P = 0.0024). High-intensity progressive resistance training improves impaired skeletal muscle characteristics and overall exercise performance in older women with CHF. These gains are largely explained by skeletal muscle and not resting cardiac adaptations.