Importance and pitfalls of molecular analysis to parasite epidemiology
Importance and pitfalls of molecular analysis to parasite epidemiology
复制标题
DOI：
10.1016/s1471-4922(03)00167-3
复制
发表时间：
2003-08-01
影响因子：
9.6
通讯作者：
Constantine, CC
中科院分区：
文献类型：
--
作者：
Constantine, CC
分子工具越来越多地被用于解决寄生虫流行病学问题。寄生虫代表了一个多样化的群体，它们可能不符合传统的种群遗传模型。检验假设同样依赖于正确的抽样、适当的工具和/或标记选择、适当的分析和仔细的解释。所有的分析方法都有假设，如果违反这些假设，结果就会失效。这里提供了一些避免常见陷阱的指导方针。
Molecular tools are increasingly being used to address questions about parasite epidemiology. Parasites represent a diverse group and they might not fit traditional population genetic models. testing hypotheses depends equally on correct sampling, appropriate tool and/or marker choice, appropriate analysis and careful interpretation. All methods of analysis make assumptions which, if violated, make the results invalid. Some guidelines to avoid common pitfalls are offered here.