Ventricular fibrillation threshold; its physiological and pharmacological importance.
Ventricular fibrillation threshold; its physiological and pharmacological importance.
复制标题
心室颤动阈值；
作者：
E. Moore;J. Spear
室颤是心肌梗死后早期猝死的主要原因之一。1室颤通常由快速室性快速性心律失常或前一次搏动的易损期内的室性期前收缩（R-on-T现象）引发。2快速性心律失常或室性早搏的发生和维持可能是由于折返机制或异常异位活动。3.如果心肌梗死患者在进入现代冠心病监护室之前存活，并且没有心源性休克，则心律失常和室颤通常可以通过电学和药理学手段控制。本报告主要涉及最近的研究使用的实验技术，测量室颤阈值，通过施加电流的心脏。特别强调了有关引发和预防室颤的电生理学和电药理学的一些最新发现。
Ventricular fibrillation is one of the primary causes of early sudden death after myocardial infarction. 1 Ventricular fibrillation is usually initiated by either a rapid ventricular tachyarrhythmia or a premature ventricular contraction falling within the vulnerable phase of the preceding beat (R-on-T phenomenon). 2 The initiation and maintenance of the tachyarrhythmia or premature ventricular contraction can be due to either a reentrant mechanism or abnormal ectopic activity. 3 If a patient with myocardial infarction survives until admittance into a modern coronary care unit and is not in cardiogenic shock, the dysrhythmias and ventricular fibrillation can usually be controlled by electrical and pharmacological means. The present report deals primarily with recent studies using the experimental technique of measuring the ventricular fibrillation threshold by applying electrical current to the heart. Particular emphasis is placed on some of the recent findings regarding the electrophysiology and electropharmacology of initiation and prevention of ventricular fibrillation.