The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics
The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics
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DOI：
10.1016/j.neubiorev.2003.08.005
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发表时间：
2003-11-01
影响因子：
8.2
通讯作者：
Sonuga-Barke, EJS
中科院分区：
文献类型：
--
作者：
Sonuga-Barke, EJS
目前占主导地位的注意缺陷多动障碍(AD/HD)的神经认知模型将这种情况描述为执行功能障碍(EDF)，其基础是额背侧纹状体环路及其相关的多巴胺能分支(如中皮质)的障碍。相比之下。基于动机的描述侧重于改变的奖赏过程，并牵涉到额叶-腹侧纹状体奖赏回路和那些终止于腹侧纹状体，特别是伏隔核的中脑边缘分支。延迟厌恶(DEL)将AD/HD描述为一种动机风格--其特征是试图逃避或避免延迟--源于这些奖励中心的基本干扰。虽然传统上被认为是相互竞争的，但EDF和DEL模型最近被认为是两种不同发育途径的AD/HD心理-病理-生理亚型的补充，它们由不同的皮质纹状体回路支撑，并受不同的多巴胺系统分支调节。在本文中，我们更详细地描述了该模型的发展。我们详细阐述了可能支撑这两条通路的神经回路，并在神经生态框架内探索它们的发育意义。(C)2003爱思唯尔有限公司。保留所有权利。
The currently dominant neuro-cognitive model of Attention Deficit Hyperactivity Disorder (AD/HD) presents the condition as executive dysfunction (EDF) underpinned by disturbances in the fronto-dorsal striatal circuit and associated dopaminergic branches (e.g. mesocortical). In contrast. motivationally-based accounts focus on altered reward processes and implicate fronto-ventral striatal reward circuits and those meso-limbic branches that terminate in the ventral striatum especially the nucleus accumbens. One such account, delay aversion (DEL), presents AD/HD as a motivational style-characterised by attempts to escape or avoid delay-arising from fundamental disturbances in these reward centres. While traditionally regarded as competing, EDF and DEL models have recently been presented as complimentary accounts of two psycho-patho-physiological subtypes of AD/HD with different developmental pathways, underpinned by different corticostriatal circuits and modulated by different branches of the dopamine system. In the current paper we describe the development of this model in more detail. We elaborate on the neuro-circuitry possibly underpinning these two pathways and explore their developmental significance within a neuro-ecological framework. (C) 2003 Elsevier Ltd. All rights reserved.