Homochirality in biomineral suprastructures induced by assembly of single-enantiomer amino acids from a nonracemic mixture
Homochirality in biomineral suprastructures induced by assembly of single-enantiomer amino acids from a nonracemic mixture
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DOI：
10.1038/s41467-019-10383-x
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发表时间：
2019-05-24
影响因子：
16.6
通讯作者：
McKee, Marc D.
中科院分区：
文献类型：
--
作者：
Jiang, Wenge;Athanasiadou, Dimitra;McKee, Marc D.
自1848年巴斯德首次成功分离右旋酒石酸盐晶体和左旋酒石酸盐晶体以来，对于如何从对映体混合物中实现均一性的理解长期以来一直不完整。在这里，我们报道了一种手性优势效应，在这种效应中，生物矿物碳酸钙(Vaterite)可以从混合的非外消旋氨基酸体系中诱导出有组织的、三维的同手性超结构。当氨基酸L-天冬氨酸占多数时，诱导出右手(逆时针方向)同位手性球藻螺旋体，而当D-天冬氨酸占多数时，诱导出左手(顺时针)同位手性形态。出乎意料的是，掺入到同手性球状球体螺旋体中的天冬氨酸保持了与初始生长溶液相同的对映体比例，从而显示了手性转移而没有手性放大。球泡石螺旋面手性程度的变化被认为是由于大多数对映体在矿物表面组装的程度造成的。这些机械洞见可能对高水平的先进材料合成具有重大影响。
Since Pasteur first successfully separated right-handed and left-handed tartrate crystals in 1848, the understanding of how homochirality is achieved from enantiomeric mixtures has long been incomplete. Here, we report on a chirality dominance effect where organized, three-dimensional homochiral suprastructures of the biomineral calcium carbonate (vaterite) can be induced from a mixed nonracemic amino acid system. Right-handed (counter-clockwise) homochiral vaterite helicoids are induced when the amino acid L-Asp is in the majority, whereas left-handed (clockwise) homochiral morphology is induced when D-Asp is in the majority. Unexpectedly, the Asp that incorporates into the homochiral vaterite helicoids maintains the same enantiomer ratio as that of the initial growth solution, thus showing chirality transfer without chirality amplification. Changes in the degree of chirality of the vaterite helicoids are postulated to result from the extent of majority enantiomer assembly on the mineral surface. These mechanistic insights potentially have major implications for high-level advanced materials synthesis.