Very short-term beat-by-beat blood pressure variability in the supine position at rest correlates well with the nocturnal blood pressure variability assessed by ambulatory blood pressure monitoring
Very short-term beat-by-beat blood pressure variability in the supine position at rest correlates well with the nocturnal blood pressure variability assessed by ambulatory blood pressure monitoring
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DOI：
10.1038/s41440-022-00911-6
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发表时间：
2022-06-01
影响因子：
5.4
通讯作者：
Sunagawa，Kenji
中科院分区：
文献类型：
--
作者：
Kinoshita，Hiroyuki;Saku，Keita;Sunagawa，Kenji
血压变异性（BPV）是高血压危险分层的重要指标。在使用24小时动态血压（BP）监测仪评估的每日BPV中，夜间收缩压BPV被认为可以预测心血管风险。我们假设静息时的极短期BPV与夜间BPV相关，因为在没有日常运动的情况下共享自主BP调节系统。30名未经治疗的血压正常和高血压成年人在仰卧位接受30分钟连续逐搏血压记录，随后进行24小时动态血压监测（ABPM）。用Pearson相关系数评估极短期BPV（标准差（SD）、变异系数（CV））与日间和夜间BPV（SD、CV、平均真实的变异性（ARV）和标准化ARV（CV-ARV））之间的关系。极短期BPV与夜间BPV显著相关（ARV，r= 0.604，p < 0.001），但与日间BPV无相关性。这些趋势随着连续逐搏BP记录的数据长度的增加而更加明显。使用30分钟连续逐搏血压记录的最后10分钟的数据段，与使用较早的数据段相比，极短期BPV和夜间BPV之间的相关性更强。这项研究的结果表明，非常短期的BPV在休息时仰卧位可以预测夜间BPV。由于患者的ABPM负担阻碍了临床传播，因此极短期BPV有可能开发一种新的BPV指数。
Blood pressure variability (BPV) is an important indicator in risk stratification for hypertension. Among the daily BPVs assessed using a 24-h ambulatory blood pressure (BP) monitor nocturnal systolic BPV has been suggested to predict cardiovascular risks. We hypothesized that very short-term BPV at rest would correlate with nocturnal BPV because of the shared autonomic BP regulatory system under no daily exertion. Thirty untreated normotensive and hypertensive adults underwent 30-min continuous beat-by-beat BP recordings in the supine position, followed by 24-h ambulatory blood pressure monitoring (ABPM). The relationship between very short-term BPV (standard deviation (SD), coefficient of variation (CV)) and daytime and nocturnal BPV (SD, CV, average real variability (ARV), and standardized ARV (CV-ARV)) was assessed with Pearson’s correlation coefficients. Very short-term BPV correlated significantly with nocturnal BPV (ARV,r= 0.604,p< 0.001) but not with daytime BPV. These trends were more pronounced with the increasing data length of continuous beat-by-beat BP recording. Using a data segment from the last 10 min of a 30-min continuous beat-by-beat BP recording resulted in a stronger correlation between very short-term BPV and nocturnal BPV than using earlier segments. The findings of this study suggest that very short-term BPV in the supine position at rest may predict nocturnal BPV. Since the burden of ABPM for patients has hindered clinical dissemination, very short-term BPV has the potential to develop a novel index of BPV.