Effect of intake pattern of sulfated polysaccharides on its biological activity in high fat diet-fed mice
Effect of intake pattern of sulfated polysaccharides on its biological activity in high fat diet-fed mice
复制标题
高脂饮食小鼠硫酸化多糖摄入方式对其生物活性的影响
DOI：
10.1016/j.ijbiomac.2019.03.174
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发表时间：
2019-07-01
影响因子：
8.2
通讯作者：
Ai, Chunqing
中科院分区：
文献类型：
--
作者：
Liu, Yili;Sun, Xiaona;Ai, Chunqing
来自不同来源的多糖的各种有益作用已被证明与其剂量、活性基团和聚合度相关，但尚不清楚摄入模式是否影响其活性。研究表明，鲍鱼性腺硫酸多糖（AGSP）可抑制高脂饲料（HFD）喂养小鼠的体重增加和脂肪蓄积。AGSP灌胃给药对肥胖相关指标的抑制作用优于自由饮食给药。AGSP通过两种不同的模式改善HFD诱导的代谢综合征和肠道微生物群失调，但它们之间在较高分类水平上的一些差异导致特定的肠道微生物群，这可能会影响营养物质的利用和能量代谢，并导致其有益作用略有差异。本研究可为益生元多糖在日常生活中的实际应用提供指导。(C)2019 Elsevier B.V.版权所有。
Various beneficial actions of polysaccharides from different sources have shown to be associated with their dosage, active group, and polymerization degree, but it is unclear whether intake pattern affects their activities. This study showed that sulfated polysaccharides of abalone gonad (AGSP) inhibited weight gain and fat accumulation in high fat diet (HFD)-fed mice. AGSP treatment via intragastric gavage exhibited a better inhibitory effect on some obesity-related parameters in comparison with free diet. AGSP via two different patterns improved HFD-induced metabolic syndrome and gut microbiota dysbiosis, but some differences between them at the higher taxonomic levels resulted in a specific gut microbiota, which could affect nutrient utilization and energy metabolism and lead to a slight difference in its beneficial action. Taken together, this study can provide a guidance for the practical application of prebiotic polysaccharides in daily life. (C) 2019 Elsevier B.V. All rights reserved.