PYRIDINOLINE, A NON-REDUCIBLE CROSSLINK OF COLLAGEN - QUANTITATIVE-DETERMINATION, DISTRIBUTION, AND ISOLATION OF A CROSSLINKED PEPTIDE
PYRIDINOLINE, A NON-REDUCIBLE CROSSLINK OF COLLAGEN - QUANTITATIVE-DETERMINATION, DISTRIBUTION, AND ISOLATION OF A CROSSLINKED PEPTIDE
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DOI：
10.1093/oxfordjournals.jbchem.a131983
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发表时间：
1978-01-01
影响因子：
2.7
通讯作者：
MORIGUCHI, T
中科院分区：
文献类型：
--
作者：
FUJIMOTO, D;MORIGUCHI, T
吡啶啉是从牛跟腱胶原蛋白中分离出来的交联化合物。它是一个3-羟基吡啶衍生物，有3个氨基和3个羧基。测定了不同来源胶原蛋白中吡啶啉的含量。牛跟腱中吡啶的含量为0.16个残基/1000个残基，大鼠跟腱胶原中吡啶的含量为0.017个残基/1000个残基。除跟腱胶原蛋白外，大鼠滨海软骨、肋骨和股骨胶原蛋白中均含有吡啶啉。在大鼠尾腱和皮肤胶原蛋白中均未发现。从牛跟腱胶原蛋白中分离出一种含有吡啶啉的交联三链肽。肽可能参与羧基端序列、氨基端附近序列和螺旋区序列之间的分子间交联。
Pyridinoline is a crosslink compound isolated from bovine Achilles tendon collagen. It is a 3-hydroxypyridinium derivative with 3 amino and 3 carboxyl groups. The contents of pyridinoline in collagen from various sources were determined. The pyridinoline content of bovine Achilles tendon was 0.16 residue/1000 residues and that of rat Achilles tendon collagen was 0.017 residue/1000 residues. Besides Achilles tendon collagen, pyridinoline was found in collagen from coastal cartilage, rib and femoral bone of rat. It was not found in collagen from the tail tendon and skin of rat. A crosslinked, triple-chained peptide containing pyridinoline was isolated from bovine Achilles tendon collagen after digestion with pronase. The peptide may be involved in an intermolecular crosslink among a carboxyterminal sequence, a sequence near the aminoterminus and a sequence in the helical region.