Frequency of bowel movements and the future risk of Parkinson's disease
Frequency of bowel movements and the future risk of Parkinson's disease
复制标题
DOI：
10.1212/wnl.57.3.456
复制
发表时间：
2001-08-14
期刊：
影响因子：
9.9
通讯作者：
Ross, GW
中科院分区：
文献类型：
--
作者：
Abbott, RD;Petrovitch, H;Ross, GW
背景：帕金森病是常见的，虽然它的发病与临床帕金森病还没有得到很好的描述。证明便秘可以先于临床PD可以为了解疾病进展和病因提供重要线索。本报告的目的是检查排便频率和未来PD风险之间的关联。研究方法：收集了1971年至1974年檀香山心脏项目中6790名年龄在51至75岁之间的无PD男性的排便频率信息。PD事件的随访时间超过24年。结果：96名男性在平均12年的随访中发展为PD。在2/d的男性中，经统计学校正的发病率从18.9/10，000人-年持续下降（p = 0.005）。在调整了年龄、吸烟年数、咖啡摄入量、泻药使用量、慢跑以及水果、蔬菜和谷物摄入量后，
Background: Constipation is frequent in PD, although its onset in relation to clinical PD has not been well described. Demonstration that constipation can precede clinical PD could provide important clues to understanding disease progression and etiology. The purpose of this report is to examine the association between the frequency of bowel movements and the future risk of PD. Methods: Information on the frequency of bowel movements was collected from 1971 to 1974 in 6790 men aged 51 to 75 years without PD in the Honolulu Heart Program. Follow-up for incident PD occurred over a 24-year period. Results: Ninety-six men developed PD an average of 12 years into follow-up. Age-adjusted incidence declined consistently from 18.9/10,000 person-years in men with 2/day (p = 0.005). After adjustment for age, pack-years of cigarette smoking, coffee consumption, laxative use, jogging, and the intake of fruits, vegetables, and grains, men with