Analysis of incidence, mortality trends, and geographic distribution of breast cancer patients in Canada
Analysis of incidence, mortality trends, and geographic distribution of breast cancer patients in Canada
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DOI：
10.1007/s10549-019-05418-2
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发表时间：
2019-12-01
影响因子：
3.8
通讯作者：
Litvinov, Ivan V.
中科院分区：
文献类型：
--
作者：
Lagace, Francois;Ghazawi, Feras M.;Litvinov, Ivan V.
背景/目的乳腺癌是除非黑色素瘤皮肤癌外发病率最高的恶性肿瘤，也是加拿大妇女癌症相关死亡的第二大原因。许多可改变的风险因素与这种疾病的发病机制有关。本研究的目的是分析乳腺癌在加拿大的流行病学，并研究其地理分布，以帮助确定新的危险因素，这种疾病的方法三个独立的人口为基础的癌症登记处被用来回顾性分析人口统计数据，从加拿大妇女诊断为浸润性乳腺癌在所有省份和地区之间的1992年和2010年。发病率和死亡率进行了评估，在省，市，和前分拣区（FSA）的邮政编码levels.Results的整体年龄调整的发病率为114.4例每10万女性每年。6个省份和多个FSA组的发病率明显较高。1992年至2010年期间，发病率显著上升，死亡率显著下降。总死亡率为每年每100 000名女性中有31.5人死亡。然而，三个省有显着较高的死亡率。结论通过确定乳腺癌的高发区，我们的研究将有助于确定患者人群中，这种恶性肿瘤的风险较高。它也将作为未来研究的基础，以确定这种疾病的新风险因素。
Background/purpose Breast cancer is the malignancy with the highest incidence rate excluding non-melanoma skin cancers, and the second leading cause of cancer-related deaths among Canadian women. Many modifiable risk factors have been linked to the pathogenesis of this disease. The purpose of this study is to analyze the epidemiology of breast cancer in Canada and to examine its geographic distribution to help identify new risk factors for this disease.Methods Three independent population-based cancer registries were used to retrospectively analyze demographic data from Canadian women diagnosed with invasive breast cancer across all provinces and territories between 1992 and 2010. The incidence and mortality rates were assessed at the provincial, city, and forward sortation area (FSA) postal code levels.Results The overall age-adjusted incidence rate was 114.4 cases per 100,000 females per year. Six provinces and several groups of FSAs had significantly higher incidence rates. There was a significant increase in incidence and decrease in mortality rates between 1992 and 2010. The overall mortality rate was 31.5 deaths per 100,000 females per year. However, three provinces had significantly higher mortality rates.Conclusion By identifying high-incidence areas for breast cancer, our study will help identify patient populations that are at higher risk for this malignancy. It will also act as a foundation for future studies to establish novel risk factors for this disease.