Randomized Trial of Short-Course Radiotherapy Versus Long-Course Chemoradiation Comparing Rates of Local Recurrence in Patients With T3 Rectal Cancer: Trans-Tasman Radiation Oncology Group Trial 01.04
Randomized Trial of Short-Course Radiotherapy Versus Long-Course Chemoradiation Comparing Rates of Local Recurrence in Patients With T3 Rectal Cancer: Trans-Tasman Radiation Oncology Group Trial 01.04
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DOI：
10.1200/jco.2012.42.9597
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发表时间：
2012-11-01
影响因子：
45.3
通讯作者：
Mackay, John
中科院分区：
文献类型：
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作者：
Ngan, Samuel Y.;Burmeister, Bryan;Mackay, John
PurposeTo比较短期（SC）和长期（LC）新辅助放疗直肠cancer.Patients和MethodsEligible患者的局部复发（LR）率超声或磁共振成像分期T3 N 0 - 2 M0直肠腺癌12厘米内从肛门边缘。SC包括盆腔放疗5 x 5戈伊，1周，早期手术和6个疗程的辅助化疗。LC为50.4戈伊，1.8戈伊/次，5.5周，连续输注氟尿嘧啶225 mg/m2/d，手术4 ~ 6周，化疗4个疗程。中位潜在随访时间为5.9年（范围：3.0 - 7.8年）。SC和LC的3年LR率（累积发生率）分别为7.5%和4.4%（差异为3.1%; 95% CI，-2.1至8.3; P = 0.24）。对于远端肿瘤（
PurposeTo compare the local recurrence (LR) rate between short-course (SC) and long-course (LC) neoadjuvant radiotherapy for rectal cancer.Patients and MethodsEligible patients had ultrasound- or magnetic resonance imaging-staged T3N0-2M0 rectal adenocarcinoma within 12 cm from anal verge. SC consisted of pelvic radiotherapy 5 x 5 Gy in 1 week, early surgery, and six courses of adjuvant chemotherapy. LC was 50.4 Gy, 1.8 Gy/fraction, in 5.5 weeks, with continuous infusional fluorouracil 225 mg/m(2) per day, surgery in 4 to 6 weeks, and four courses of chemotherapy.ResultsThree hundred twenty-six patients were randomly assigned; 163 patients to SC and 163 to LC. Median potential follow-up time was 5.9 years (range, 3.0 to 7.8 years). Three-year LR rates (cumulative incidence) were 7.5% for SC and 4.4% for LC (difference, 3.1%; 95% CI, -2.1 to 8.3; P = .24). For distal tumors (