Sex differences in emotion- and reward-related neural responses predicting increases in substance use in adolescence.
Sex differences in emotion- and reward-related neural responses predicting increases in substance use in adolescence.
复制标题
情绪和奖励相关神经反应的性别差异预示着青春期物质使用的增加。
DOI：
10.1016/j.bbr.2023.114499
复制
发表时间：
2023
影响因子：
2.7
通讯作者：
Thompson,JamesC
中科院分区：
文献类型：
--
作者：
Chaplin,TaraM;Curby,TimothyW;Gonçalves,StefanieF;Kisner,MalloryA;Niehaus,ClaireE;Thompson,JamesC
青少年药物使用是一个重大的公共卫生问题，需要有效预防药物使用。为了制定有效的预防措施，重要的是要确定预测青少年药物使用增加的神经生物学风险因素，并了解风险机制的潜在性别差异。本研究采用功能性磁共振成像和分层线性模型，以检查负面情绪和奖励相关的神经反应，在青春期早期预测增长的物质使用到青春期中期的81名青年，性别。在12-14岁时评估了青少年对负面情绪刺激和金钱奖励的神经反应。青少年在12-14岁时以及6个月、1年、2年和3年随访时报告了物质使用情况。青少年的神经反应并没有预测物质使用的开始（是/否），但在用户中，神经反应预测物质使用频率的增长。对于女孩来说，在青春期早期，右杏仁核对负面情绪刺激的反应增强，可以预测青春期中期物质使用频率的增长。对于男孩来说，钝化的左丘脑核和双侧腹内侧前额叶皮层对金钱奖励的反应预测了物质使用频率的增长。研究结果表明，不同的情绪和奖励相关的预测青少年女孩与男孩的物质使用的发展。
Adolescent substance use is a significant public health problem and there is a need for effective substance use preventions. To develop effective preventions, it is important to identify neurobiological risk factors that predict increases in substance use in adolescence and to understand potential sex differences in risk mechanisms. The present study used functional magnetic resonance imaging and hierarchical linear modeling to examine negative emotion- and reward-related neural responses in early adolescence predicting growth in substance use to middle adolescence in 81 youth, by sex. Adolescent neural responses to negative emotional stimuli and monetary reward receipt were assessed at age 12–14. Adolescents reported on substance use at age 12–14 and at 6 month, and 1, 2, and 3 year follow-ups. Adolescent neural responses did not predict initiation of substance use (yes/no), but, among users, neural responses predicted growth in substance use frequency. For girls, heightened right amygdala responses to negative emotional stimuli in early adolescence predicted growth in substance use frequency through middle adolescence. For boys, blunted left nucleus accumbens and bilateral ventromedial prefrontal cortex responses to monetary reward predicted growth in substance use frequency. Findings suggest different emotion and reward-related predictors of the development of substance use for adolescent girls versus boys.