Nicotinic involvement in memory function in zebrafish
Nicotinic involvement in memory function in zebrafish
复制标题
DOI：
10.1016/j.ntt.2004.06.010
复制
发表时间：
2004-11-01
影响因子：
2.9
通讯作者：
Chen, E
中科院分区：
文献类型：
--
作者：
Levin, ED;Chen, E
斑马鱼是研究脑功能分子机制的新兴模型。为了研究斑马鱼行为的神经基础，我们必须了解斑马鱼的行为功能，以及大脑功能的扰动是如何改变它的。这项研究确定了尼古丁对斑马鱼记忆功能的作用。用我们发展的利用延迟空间交替(DSA)评估斑马鱼记忆的方法，我们测定了急性尼古丁对斑马鱼记忆功能的剂量效应函数。与啮齿动物和灵长类动物一样，低剂量的尼古丁可以改善斑马鱼的记忆力，而高剂量的尼古丁会减弱这种作用，并可能损害记忆。这项研究表明，尼古丁影响斑马鱼的记忆功能，就像对大鼠、小鼠、猴子和人类一样。现在，斑马鱼可以用来帮助理解尼古丁对记忆影响的关键分子机制。(C)2004 Elsevier Inc.保留所有权利。
Zebrafish are an emerging model for the study of the molecular mechanisms of brain function. To conduct studies of the neural bases of behavior in zebrafish, we must understand the behavioral function of zebrafish and how it is altered by perturbations of brain function. This study determined nicotine actions on memory function in zebrafish. With the methods that we have developed to assess memory in zebrafish using delayed spatial alternation (DSA), we determined the dose effect function of acute nicotine on memory function in zebrafish. As in rodents and primates, low nicotine doses improve memory in zebrafish, while high nicotine doses have diminished effect and can impair memory. This study shows that nicotine affects memory function in zebrafish much like in rats, mice, monkeys and humans. Now, zebrafish can be used to help understand the molecular mechanisms crucial to nicotine effects on memory. (C) 2004 Elsevier Inc. All rights reserved.