Symptoms of gastro-oesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population
Symptoms of gastro-oesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population
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DOI：
10.1046/j.1365-2036.2003.01769.x
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发表时间：
2004-01-01
影响因子：
7.6
通讯作者：
Rodriguez-Artalejo, F
中科院分区：
文献类型：
--
作者：
Diaz-Rubio, M;Moreno-Elola-Olaso, C;Rodriguez-Artalejo, F
目的：测量胃食管反流症状的患病率，并确定相关因素在一个有代表性的样本的西班牙population.Methods：2500名受试者的电话调查进行了验证问卷。胃食管反流症状（定义为存在烧心或反酸）和他们的临床特征与潜在的危险因素的关联进行了总结使用的优势比（OR）通过多元logistic regulation.Results获得：响应率为71.2%。胃食管反流症状的年患病率为31.6%[95%置信区间（CI），29.8-33.4]，每周患病率为9.8%（95% CI，8.6-10.9）。胃食管反流症状与超重有关（OR，1.53; 95% CI，1.23-1.92），肥胖（OR，1.74; 95%CI，1.30-2.32），心身症状评分（OR，2.98; 95% CI，2.41-3.67）和直系亲属中存在胃食管反流症状（OR，1.61; 95% CI，1.17-2.23）。持续时间大于或等于10年的胃食管反流症状在肥胖受试者（OR，1.92; 95%CI，1.14-3.22）和直系亲属有胃食管反流症状的受试者（OR，2.42; 95%CI，1.44-4.06）中更常见。与胃食管反流症状持续时间小于或等于1年相关的因素是配偶有胃食管反流症状（OR，2.33; 95% CI，1.39-3.9）和每周服用1-5片阿司匹林结论：在西班牙，频繁的胃食管反流症状的患病率低于在其他西方人群中观察到的。心身症状评分是与胃食管反流症状最密切相关的因素。长期胃食管反流症状与某些遗传因素（肥胖、胃食管反流症状家族史）相关，而短期胃食管反流症状与可能的环境因素相关。
Aim: To measure the prevalence of gastro-oesophageal reflux symptoms and to identify associated factors in a representative sample of the Spanish population.Methods: A telephone survey of 2500 subjects was performed using a validated questionnaire. The association of gastro-oesophageal reflux symptoms (defined as the presence of heartburn or acid regurgitation) and their clinical characteristics with potential risk factors was summarized using the odds ratios (OR) obtained by multiple logistic regression.Results: The response rate was 71.2%. The annual prevalence of gastro-oesophageal reflux symptoms was 31.6%[95% confidence interval (CI), 29.8-33.4] and the weekly prevalence was 9.8% (95% CI, 8.6-10.9). Gastro-oesophageal reflux symptoms were associated with excess weight (OR, 1.53; 95% CI, 1.23-1.92), obesity (OR, 1.74; 95% CI, 1.30-2.32), the psychosomatic symptom score (OR, 2.98; 95% CI, 2.41-3.67) and the presence of gastro-oesophageal reflux symptoms in a direct family member (OR, 1.61; 95% CI, 1.17-2.23). Gastro-oesophageal reflux symptoms of greater than or equal to 10 years' duration were more frequent in obese subjects (OR, 1.92; 95% CI, 1.14-3.22) and those with a direct family member with gastro-oesophageal reflux symptoms (OR, 2.42; 95% CI, 1.44-4.06). Factors associated with gastro-oesophageal reflux symptoms of less than or equal to 1 year duration were a spouse with gastro-oesophageal reflux symptoms (OR, 2.33; 95% CI, 1.39-3.9) and the consumption of 1-5 aspirins/week (OR, 1.70; 95% CI, 1.01-2.86).Conclusions: The prevalence of frequent gastro-oesophageal reflux symptoms in Spain is lower than that observed in other Western populations. The psychosomatic symptom score is the factor most strongly associated with gastro-oesophageal reflux symptoms. Long-term gastro-oesophageal reflux symptoms are associated with certain genetic factors (obesity, family history of gastro-oesophageal reflux symptoms), whereas short-term gastro-oesophageal reflux symptoms are associated with factors of probable environmental nature.