Random change in cortical load representation suggests distinct control of posture and movement
Random change in cortical load representation suggests distinct control of posture and movement
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DOI：
10.1038/nn1420
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发表时间：
2005-04-01
影响因子：
25
通讯作者：
Scott, SH
中科院分区：
文献类型：
--
作者：
Kurtzer, I;Herter, TM;Scott, SH
准确地保持固定的肢体姿势和快速移动的姿势既是日常技能的基础，包括手持和举起一杯咖啡，也是专家技能的基础，例如奥运会摔跤运动员握住和投掷对手。肢体运动控制中的一个基本问题是，大脑是通过一个单一的、强大的控制过程来管理这些相互对立的姿势和运动目标，还是每个目标都参与了一个专门的控制过程。我们通过研究猕猴初级运动皮质中的单个神经元如何在姿势和运动任务中代表机械负荷来解决这个问题。值得注意的是，大约一半表达负荷相关活动的神经元只在姿势或运动时表达。此外，那些在两个任务中都有负荷相关活动的神经元在两个任务之间随机切换其反应的大小。负荷表征的这些随机变化表明了特殊的控制过程，一个用于姿势，另一个用于运动。
Accurately maintaining a fixed limb posture and quickly moving between postures underlies both everyday skills, including holding and lifting a cup of coffee, and expert skills, such as an Olympic wrestler's holding and throwing an opponent. A fundamental question in limb motor control is whether the brain manages these contrasting goals of posture and movement through a single, robust control process or whether each engages a specialized control process. We addressed this question by examining how individual neurons in the primary motor cortex of macaque monkeys represent mechanical loads during posture and movement tasks. Notably, approximately half of the neurons that expressed load-related activity did so exclusively during either posture only or movement only. Further, those neurons with load-related activity during both tasks randomly switched their magnitude of response between tasks. These random changes in load representation suggest specialized control processes, one for posture and one for movement.