PHOTOSENSITIZATION OF MALIGNANT TUMORS
PHOTOSENSITIZATION OF MALIGNANT TUMORS
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DOI：
10.1002/ssu.2980020104
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发表时间：
1986-01-01
期刊：
影响因子：
--
通讯作者：
DOUGHERTY T J
中科院分区：
文献类型：
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作者：
DOUGHERTY T J
光动力疗法是一种治疗恶性肿瘤的新的实验方法，它利用光敏剂（血卟啉衍生物或二血卟啉醚）的相对选择性保留及其在穿透可见光激活时引发有效光动力反应的能力。这种疗法应用于支气管、膀胱、皮肤和其他几个部位的肿瘤，即使在晚期病例中也显示出安全性和有效性。已经证明可以根除支气管和膀胱的早期肿瘤。光敏剂在肿瘤中的选择性保留显然与这些材料的聚集体相对较大的尺寸有关，引起网状内皮细胞的吞噬作用，并阻止肿瘤间质液的快速清除以及随后细胞的亲脂性成分的摄取。光激活（通常由激光通过光纤传递）后，敏化剂会产生单线态氧，即明显的细胞毒性剂，导致血管损伤和肿瘤细胞损伤。
Photodynamic therapy is a new, experimental method of treating malignant tumors by utilizing the relatively selective retention of the photosensitizer (hematoporphyrin derivative or dihematoporphyrin ether) and its ability to elicit an efficient photodynamic reaction upon activation with penetrating viable light. Application of this therapy to tumors in the bronchus, bladder, skin, and several other sites has demonstrated both safety and efficacy, even in advanced cases. Eradication of early stage tumors in the bronchus and bladder has been demonstrated. Selective retention of the photosensitizers in tumors is apparently related to the relatively large size of the aggregates of these materials causing phagocytosis by reticuloendothelial cells as well as preventing rapid clearance from tumor interstitial fluid and subsequent uptake in lipophylic components of cells. Upon light activation, generally delivered from lasers via fiber optics, the sensitizers generate singlet oxygen, the apparent cytotoxic agent, causing both vascular damage and injury to tumor cells.