Serum Antioxidant Status Is Associated with Metabolic Syndrome among US Adults in Recent National Surveys
Serum Antioxidant Status Is Associated with Metabolic Syndrome among US Adults in Recent National Surveys
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DOI：
10.3945/jn.110.136580
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发表时间：
2011-05-01
影响因子：
4.2
通讯作者：
Zonderman, Alan B.
中科院分区：
文献类型：
--
作者：
Beydoun, May A.;Shroff, Monal R.;Zonderman, Alan B.
潜在的抗炎和抗氧化作用最近归因于天然存在的微量营养素。它们对代谢综合征（MetS）的差异影响的程度和幅度尚不清楚。我们研究了血清抗氧化状态和MetS之间的关系。分析了NHANES 2001-2006年20-85岁成年人的横断面数据（n= 3008-9099）。MetS由国家胆固醇教育计划成人治疗小组III （NCEP ATP III）定义，也通过升高的稳态模型评估胰岛素抵抗（HOMA-IR）、c反应蛋白（CRP）和高尿酸血症。血清抗氧化剂包括视黄醇、视黄醇酯、类胡萝卜素[α -胡萝卜素、β -胡萝卜素（顺式+反式）、β -隐黄质、叶黄素+玉米黄质、总番茄红素]、维生素E和维生素c。美国成年人的MetS （NCEP ATP ii）患病率为男性32.0%，女性29.5%。即使在控制了总胆固醇和甘油三酯等其他潜在混杂因素后，与没有MetS的成年人相比，患有MetS的成年人血清类胡萝卜素浓度始终较低。在全多元logistic回归模型中，维生素E与MetS没有显著关系，而视黄醇+视黄醇酯仅在男性中与MetS呈负相关。后者也与CRP升高呈负相关，与高尿酸血症呈正相关。维生素C表现出与血清类胡萝卜素相似的模式，与MetS（二元）、HOMA-IR和高尿酸血症呈反比线性相关。未来关于饮食和生活方式改变的干预研究必须进行，以评估改变血清抗氧化剂浓度的效用，特别是类胡萝卜素，因为它们在美国成年MetS患者中处于次优水平，用于预防2型糖尿病和各种心血管终点。中国生物医学工程学报，2011,31(3):444 - 444。
Potential antiinflammatory and antioxidant effects were recently ascribed to naturally occurring micronutrients. The extent and magnitudes of their differential effects on the metabolic syndrome (MetS) are still unknown. We examined the association between serum antioxidant status and MetS. NHANES 2001-2006 cross-sectional data among adults aged 20-85 y were analyzed (n= 3008-9099). MetS was defined with the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and also by elevated homeostatic model assessment insulin resistance (HOMA-IR), C-reactive protein (CRP) and hyperuricemia. Serum antioxidants included retinol, retinyl esters, carotenoids [alpha-carotene, beta-carotene (cis+trans), beta-cryptoxanthin, lutein+zeaxanthin, total lycopene], vitamin E, and vitamin C. MetS (NCEP ATP Ill) prevalence in U.S. adults was 32.0% among men and 29.5% among women. Adults with MetS had consistently lower serum carotenoid concentrations compared with those without MetS, even after controlling for total cholesterol and TG among other potential confounders. Vitamin E had no significant relationship with MetS in the full multiple logistic regression model, whereas retinol+retinyl esters were inversely related to MetS among men only. The latter were also inversely related to elevated CRP and positively associated with hyperuricemia. Vitamin C exhibited a similar pattern to serum caratenoids with an inverse linear association with MetS (binary), HOMA-IR, and hyperuricemia. Future intervention studies of dietary and lifestyle change must be conducted to assess the utility of modifying serum antioxidant concentrat ons, especially carotenoids, given their suboptimal levels among U.S. adults with MetS, for the prevention of type 2 diabetes and various cardiovascular endpoints. J. Nutr. 141 903-913, 2011.