Aberrant movement-related somatosensory cortical activity mediates the extent of the mobility impairments in persons with cerebral palsy.
Aberrant movement-related somatosensory cortical activity mediates the extent of the mobility impairments in persons with cerebral palsy.
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DOI：
10.1113/jp282898
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发表时间：
2022-08
影响因子：
5.5
通讯作者：
Kurz, Max J.
中科院分区：
文献类型：
--
作者：
Trevarrow, Michael P.;Taylor, Brittany K.;Reelfs, Anna M.;Wilson, Tony W.;Kurz, Max J.
大量临床报道表明，脑性瘫痪患者存在本体感觉、立体知觉和触觉辨别缺陷。目前的共识是，这些感知的改变可归因于躯体感觉皮质活动的异常。从这些数据可以推断，脑性瘫痪患者在运动动作过程中没有充分处理正在进行的感觉反馈，这加剧了他们行动能力障碍的程度。然而，这一假设尚未得到直接检验。我们使用脑磁图(MEG)脑成像来解决这一知识缺口，方法是量化22名CP患者和25名神经典型(NT)对照组在静息和踝足屈等长运动任务时对胫神经施加电刺激所引起的躯体感觉动力学。我们还量化了扫描仪外参与者的时空步态生物力学。与文献一致的是，我们的结果证实，与NT对照组相比，CP患者的躯体感觉皮质活动强度更弱。我们的结果还表明，在等长踝关节力量任务中，躯体感觉皮质反应的强度明显弱于静止状态。最重要的是，我们的结果表明，在踝关节足底屈力产生任务中，体感皮层活动的强度中介了安静时体感皮层活动与步行速度和步长之间的关系。这些结果表明，患有CP的年轻人在等长力产生过程中有异常的躯体感觉皮质活动，这最终导致了该患者群体中出现的行动障碍的程度。脑磁图的脑成像被用来确定运动时感觉反馈对脑瘫患者行动能力的影响。与神经类型的同龄人相比，脑瘫患者在休息和运动时的躯体感觉皮质活动减少。此外，运动时的体感皮层活动在静息时的体感皮层活动与活动之间的关系中起中介作用。这些结果表明，感觉运动整合困难可能是导致该患者群体中出现的活动障碍的原因之一。
There are numerous clinical reports that persons with cerebral palsy (CP) have proprioceptive, stereognosis and tactile discrimination deficits. The current consensus is that these altered perceptions are attributable to aberrant somatosensory cortical activity. It has been inferred from these data that persons with CP do not adequately process ongoing sensory feedback during motor actions, which accentuates the extent of their mobility impairments. However, this hypothesis has yet to be directly tested. We used magnetoencephalographic (MEG) brain imaging to address this knowledge gap by quantifying the somatosensory dynamics evoked by applying electrical stimulation to the tibial nerve in 22 persons with CP and 25 neurotypical (NT) controls while at rest and during an ankle plantarflexion isometric force motor task. We also quantified the spatiotemporal gait biomechanics of participants outside the scanner. Consistent with the literature, our results confirmed that the strength of somatosensory cortical activity was weaker in the persons with CP compared to the NT controls. Our results also showed that the strength of the somatosensory cortical responses were significantly weaker during the isometric ankle force task than at rest. Most importantly, our results showed that the strength of somatosensory cortical activity during the ankle plantarflexion force production task mediated the relationship between somatosensory cortical activity at rest and both walking velocity and step length. These results suggest that youth with CP have aberrant somatosensory cortical activity during isometric force generation, which ultimately contributes to the extent of mobility impairments seen in this patient population. Magnetoencephalographic brain imaging was used to determine the effect of sensory feedback during movement on mobility in persons with cerebral palsy. Persons with cerebral palsy had reduced somatosensory cortical activity at rest and during movement compared with their neurotypical peers. Further, the somatosensory cortical activity during movement mediated the relationship between somatosensory cortical activity at rest and mobility. These results indicate that difficulties in sensorimotor integration may contribute to the mobility impairments seen in this patient population.
影响因子：
2.3
作者：
Pantzar-Castilla E;Chen BP;Miller F;Riad J
通讯作者：
Riad J