Palladium-catalyzed intermolecular coupling of aryl halides and amides
Palladium-catalyzed intermolecular coupling of aryl halides and amides
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DOI：
10.1021/ol005654r
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发表时间：
2000-04-20
期刊：
影响因子：
5.2
通讯作者：
Buchwald, SL
中科院分区：
文献类型：
--
作者：
Yin, JJ;Buchwald, SL
芳基卤化物和酰胺之间的第一个一般的分子间C-N键形成反应是使用以Xantphos为配体的钯催化剂实现的。芳基三氟甲磺酸酯、氨基甲酸酯和磺酰胺也是用于酰胺化的可行底物，其在45-110 ℃下在1- 4mol%的Pd催化剂下进行，产率为66-99%，并表现出良好的官能团相容性。
The first general intermolecular C-N bond-forming reactions between aryl halides and amides were realized using a palladium catalyst with Xantphos as the ligand, Aryl triflates, carbamates, and sulfonamides are also viable substrates for the amidations, which proceed at 45-110 degrees C with 1-4 mol % of Pd catalyst in 66-99% yields and exhibit good functional group compatibility.