ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE ( AMANTADINE )
ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE ( AMANTADINE )
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DOI：
10.1126/science.144.3620.862
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发表时间：
1964-01-01
期刊：
影响因子：
56.9
通讯作者：
MCGAHEN, JW
中科院分区：
文献类型：
--
作者：
DAVIES, WL;HOFFMANN, CE;MCGAHEN, JW
1-金刚烷胺（金刚烷胺）在组织培养、鸡胚和小鼠中对流感病毒感染具有选择性、可重复性、剂量相关性抑制作用。该化合物不是杀病毒的，似乎通过干扰病毒对宿主细胞的渗透而起作用。在小鼠的流感感染中，在感染时治疗的效果最好;然而，在感染后72小时内延迟治疗也有显著的抗病毒活性。病毒抑制不完全，存活者对原始感染病毒的攻击感染具有免疫力。
1-Adamantanamine (amantadine) causes a selective, reproducible, dose-related inhibition of influenza infections in tissue culture, chick embryos and mice. The compound is not virucidal and appears to act by interfering with the penetration of the host cell by the virus. In influenza infections of mice, greatest efficacy occurs with treatment at the time of infection; however, there is significant antiviral activity with treatment delayed up to 72 hours after infection. Virus inhibition is not complete and survivors are immune to a challenge infection with the original infecting virus.