Functional MRI detection of pharmacologically induced memory impairment
Functional MRI detection of pharmacologically induced memory impairment
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DOI：
10.1073/pnas.012467899
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发表时间：
2002-01-08
影响因子：
11.1
通讯作者：
Albert, M
中科院分区：
文献类型：
--
作者：
Sperling, R;Greve, D;Albert, M
为了检查与药理学诱导的记忆损伤相关的脑激活改变，我们使用功能性磁共振成像（fMRI）研究了劳拉西泮和东莨菪碱对面孔-名称联想编码范式的影响。10名健康青年受试者分4次扫描，间隔2周；他们在两次安慰剂扫描期间静脉注射生理盐水，然后在双盲、随机、交叉设计中交替静脉注射劳拉西泮（1mg）或东莨菪碱（0.4 mg）。研究人员检查了解剖感兴趣区域（roi）内激活的程度和幅度，以确定安慰剂疗程中激活的可重复性和药理学效应的区域特异性。在编码新面孔-名字对期间，所有roi的激活在两次安慰剂扫描中是一致的（与视觉固定相比）。在给予氯西泮或东莨菪碱的情况下，海马、梭状回和下前额叶ROIs的激活程度和强度都明显降低，但纹状皮层的激活没有明显改变。两种药物都损害了扫描后记忆测量的表现，并且在海马和梭状回roi中发现了记忆表现与激活程度之间的显著相关性。这些发现表明，通过使用可重复的实验范式，fMRI可以检测到药物效应，并且损害记忆的药物也会减少特定大脑区域的激活，这些区域被认为是复杂记忆过程的附属。
To examine alterations in brain activation associated with pharmacologically induced memory impairment, we used functional MRI (fMRI) to study the effects of lorazepam and scopolamine on a face-name associative encoding paradigm. Ten healthy young subjects were scanned on four occasions, 2 weeks apart; they were administered i.v. saline during two placebo-scanning sessions and then alternately administered i.v. lorazepam (1 mg) or scopolamine (0.4 mg) in a double-blind, randomized, cross-over design. Both the extent and magnitude of activation within anatomic regions of interest (ROIs) were examined to determine the reproducibility of activation in the placebo sessions and the regional specificity of the pharmacologic effects. Activation within all ROIs was consistent across the two placebo scans during the encoding of novel face-name pairs (compared with visual fixation). With the administration of either lorazepam or scopolamine, significant decreases were observed in both the extent and magnitude of activation within the hippocampal, fusiform, and inferior prefrontal ROIs, but no significant alterations in activation in the striate cortex were found. Both medications impaired performance on postscan memory measures, and significant correlations between memory performance and extent of activation were found in hippocampal and fusiform ROIs. These findings suggest that pharmacologic effects can be detected with fMRI by using a reproducible experimental paradigm and that medications that impair memory also diminish activation in specific brain regions thought to subserve complex memory processes.