A novel procedure for the mechanical characterization of the uterine cervix during pregnancy
A novel procedure for the mechanical characterization of the uterine cervix during pregnancy
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DOI：
10.1016/j.jmbbm.2012.11.020
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发表时间：
2013-11-01
影响因子：
3.9
通讯作者：
Mazza, Edoardo
中科院分区：
文献类型：
--
作者：
Badir, Sabrina;Bajka, Michael;Mazza, Edoardo
提出了一种体内测量程序来表征怀孕期间人类子宫颈的机械行为。基于抽吸方法，开发了一种新仪器，以提供本质上安全且易于使用的机械测试技术。对非孕妇进行了初步测量，以制定适当的测量方案。进行逆分析以确定宫颈组织的代表性模型方程。该模型用于基于有限元的参数研究，重点关注与实验相关的不确定性。在此基础上，建立了一种新颖的程序，首次能够对 50 名孕妇在妊娠期间进行 600 多次应用进行机械测量。对每个妊娠期的平均组织反应进行逆分析，以确定妊娠过程中子宫颈的代表性模型方程。 (C) 2012 Elsevier Ltd. 保留所有权利。
An in-vivo measurement procedure is presented to characterize the mechanical behavior of human uterine cervix during pregnancy. Based on the aspiration method, a new instrument was developed to provide an inherently safe and easy-to-use mechanical testing technique. Initial measurements were performed on non-pregnant women to develop an appropriate measurement protocol. An inverse analysis was carried out to determine representative model equations for cervical tissue. This model was used in a FE based parametric study focusing on the uncertainties related to the experiment. On this basis, a novel procedure was established which enabled for the first time to conduct mechanical measurements on 50 pregnant women in over 600 applications during gestation. An inverse analysis of the average tissue response at each trimester was performed to determine representative model equations for the cervix in the course of pregnancy. (C) 2012 Elsevier Ltd. All rights reserved.