REGULATION OF TRANSLATION AND CELL-GROWTH BY EIF-4E

REGULATION OF TRANSLATION AND CELL-GROWTH BY EIF-4E
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DOI:
10.1016/0300-9084(94)90185-6
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发表时间:
1994-01-01
期刊:
影响因子:
3.9
通讯作者:
SONENBERG, N
SONENBERG, N
中科院分区:
生物学3区
文献类型:
--
作者:
SONENBERG, N

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这篇综述讨论了蛋白质合成起始过程中一个关键控制步骤的调节,即 mRNA 与核糖体的结合。特别关注帽结合因子 eIF-4E 的磷酸化,以及该因子在细胞生长调节中的作用。
This review discusses the regulation of a key controlling step in the initiation of protein synthesis, the binding of mRNA to ribosomes. Particular focus is given to the phosphorylation of the cap-binding factor, eIF-4E, and the role of this factor in the regulation of cell growth.