Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat.
Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat.
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大鼠雌激素依赖性垂体瘤生长的数量性状位点。
DOI：
10.1007/s003359900586
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Gorski,J
中科院分区：
文献类型：
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作者：
Wendell,DL;Gorski,J
生长控制对生物学具有基本的重要性，特别是对癌症研究至关重要。当失去对正常生长过程的控制时，肿瘤就会发展。大鼠脑垂体是控制雌激素依赖性生长的模型系统。长期雌激素治疗可导致Fischer 344(F344)大鼠的脑下垂体不受控制地生长，但对Brown挪威(BN)大鼠则不能。我们在F344与BN杂交的F2代中定位了5个雌激素依赖型脑下垂体肿块(EDPM)的数量性状基因座(QTL)。这些QTL位于大鼠染色体(CHR)2、3、5和9上，解释了F2代55%的遗传变异。我们还发现了大鼠Chr14上存在QTL的提示性证据。对于Edpm2-1、Edpm2-2、Edpm3和Edpm5，F344等位基因如预期的那样对应于垂体质量的增加。令人惊讶的是，对于Edpm9和建议的Chr 14上的QTL，BN等位基因对应于垂体质量的增加。我们还发现了Edpm3和Edpm9之间以及Edpm5和建议的Chr14上的QTL之间存在互作(上位性)的证据。
Growth control is of fundamental importance to biology in general and of critical importance to cancer research in particular. Tumors develop when control of the normal growth process is lost. The rat pituitary is a model system for control of estrogen-dependent growth. Chronic estrogen treatment induces uncontrolled growth in the pituitaries of Fischer 344 (F344) rats, but not of Brown Norway (BN) rats. We have identified five quantitative trait loci (QTL) for estrogen-dependent pituitary mass (Edpm) in an F2intercross of F344 and BN. These QTL reside on rat Chromosomes (Chrs) 2, 3, 5, and 9 and explain a total of 55% of the genetic variance in the F2. We have also detected suggestive evidence for a QTL on rat Chr 14. ForEdpm2- 1, Edpm2- 2, Edpm3, andEdpm5, the F344 allele corresponds with increased pituitary mass, as expected. Surprisingly, forEdpm9and the suggested QTL on Chr 14, the BN allele corresponds with increased pituitary mass. We also find evidence for interaction (epistasis) betweenEdpm3andEdpm9and betweenEdpm5and the suggested QTL on Chr 14.