Interleukin 13 is a B cell stimulating factor.
Interleukin 13 is a B cell stimulating factor.
复制标题
白介素13是B细胞刺激因子。
DOI：
10.1084/jem.179.1.135
复制
发表时间：
1994-01-01
影响因子：
15.3
通讯作者：
Ferrara, P
中科院分区：
文献类型：
--
作者：
Defrance, T;Carayon, P;Billian, G;Guillemot, J C;Minty, A;Caput, D;Ferrara, P
新近克隆的人白介素13(IL-13)是一种表达于活化T细胞的新型细胞因子，可抑制脂多糖激活的单核细胞产生炎性细胞因子。IL-13基因编码的蛋白质是一种名为P600的小鼠Th2产物的人类同源物。在这里，我们发现IL-13在B细胞成熟途径的不同阶段起作用：(A)它促进静止B细胞上CD23/Fc epsilon RII和II类MHC抗原的表达；(B)它与抗Ig和抗CD40抗体一起刺激B细胞增殖；(C)它诱导IgE合成。因此，IL-13对B细胞的生物活性与以前归因于IL-4的生物活性谱很大程度上重叠。目前的观察表明，除IL-4外，IL-13在变态反应性疾病的发生发展中可能是一个重要的因素。
The recently cloned human interleukin 13 (IL-13) is a novel cytokine expressed in activated T cells that has been shown to inhibit inflammatory cytokine production by lipopolysaccharide-activated monocytes. The protein encoded by the IL-13 cDNA is the human homologue of a mouse Th2-product called P600. Here, we show that IL-13 acts at different stages of the B cell maturation pathway: (a) it enhances the expression of CD23/Fc epsilon RII and class II MHC antigens on resting B cells; (b) it stimulates B cell proliferation in combination with anti-Ig and anti-CD40 antibodies; and (c) it induces IgE synthesis. Thus, the spectrum of the biological activities of IL-13 on B cells largely overlaps that previously ascribed to IL-4. The present observations suggest that IL-13 may be an important factor, in addition to IL-4, in the development of allergic diseases.