THE BEHAVIOR OF RESIDUAL AXONS IN PARTIALLY DENERVATED MUSCLES OF THE MONKEY
THE BEHAVIOR OF RESIDUAL AXONS IN PARTIALLY DENERVATED MUSCLES OF THE MONKEY
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DOI：
10.1084/jem.93.3.207
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发表时间：
1951-01-01
影响因子：
15.3
通讯作者：
SMALL, WT
中科院分区：
文献类型：
--
作者：
EDDS, MV;SMALL, WT
恒河猴的腿肌肉进行了研究后，通过手术消除从腰骶丛进入坐骨神经的轴突的25%至90%的部分去神经。研究内容包括观察受累肌肉的功能、萎缩率和程度以及神经组织学表现（Carey’s氯化金法）。4例腓神经和胫神经残余神经纤维破坏83 ~ 90%，小腿肌肉严重麻痹。术后160天，功能没有改善，受影响的肌肉明显萎缩。这些肌肉的组织学检查未能发现更多的零星侧支再生的残余轴突。2例患者术后63天和200天分别有50%和75%的腓神经和胫神经纤维保持完整。在这些病例中，手术腿的功能几乎正常，所有肌肉的重量在对侧正常腿的11%以内。组织学观察和终板神经纤维比率计数显示，许多残留的轴突有再生的侧支进入失神经终板。侧支再生是不完全的，但是，许多终板仍然没有神经支配。这些结果表明，灵长类动物麻痹肌肉中的残留轴突不像其他先前研究的哺乳动物那样容易侧支再生。
Leg muscles of the rhesus monkey were studied following partial denervation produced by surgical elimination of from 25 to 90% of the axons entering the sciatic nerve from the lumbosacral plexus. The investigation included observations on functions, rate and degree of atrophy, and neurohistological appearance (Carey''s gold chloride method) of the affected muscles. In 4 cases, from 83 to 90% of the residual nerve fibers in the peroneal and tibial nerves were destroyed and a severe paresis of the leg muscles was produced. No functional improvement was noted up to 160 days after operation, and the affected muscles became markedly atrophic. Histological exa-mination of these muscles failed to reveal more than sporadic collateral regeneration of the residual axons. In 2 cases, 50 and 75% of the peroneal and tibial nerve fibers remained intact 63 and 200 days, respectively, after operation. The operated legs in these cases functioned almost normally and all muscles weighed within 11% of those of the contralateral, normal leg. Histological study and counts of end-plate nerve fiber ratios, showed that many residual axons had regenerated collateral branches which entered denervated end-plates. Collateral regeneration was incomplete, however, and many end-plates remained without innervation. These results indicate that residual axons in paretic muscles of a primate do not regenerate collateraly as readily as do those of other previously studied mammals.