Elastic properties of polyunsaturated phosphatidylethanolamines influence rhodopsin function.
Elastic properties of polyunsaturated phosphatidylethanolamines influence rhodopsin function.
复制标题
多不饱和磷脂酰乙醇胺的弹性特性影响视紫红质功能。
DOI：
10.1039/c2fd20095c
复制
发表时间：
2013
影响因子：
3.4
通讯作者：
Gawrisch,Klaus
中科院分区：
文献类型：
--
作者：
TeagueJr,WalterE;Soubias,Olivier;Petrache,Horia;Fuller,Nola;Hines,KirkG;Rand,RPeter;Gawrisch,Klaus
Membranes with a high content of polyunsaturated phosphatidylethanolamines (PE) facilitate formation of metarhodopsin-II (MII), the photointermediate of bovine rhodopsin that activates the G protein transducin. We determined whether MII-formation is quantitatively linked to the elastic properties of PEs. Curvature elasticity of monolayers of the polyunsaturated lipids 18 : 0–22 : 6n − 3PE, 18 : 0–22 : 5n − 6PE and the model lipid 18 : 1n − 9–18 : 1n − 9PE were investigated in the inverse hexagonal phase. All three lipids form lipid monolayers with rather low spontaneous radii of curvature of 26–28 Å. In membranes, all three PEs generate high negative curvature elastic stress that shifts the equilibrium of MI/MII photointermediates of rhodopsin towards MII formation.
