[18F]fluorodeoxyglucose positron emission tomography and its prognostic value in lung cancer
[18F]fluorodeoxyglucose positron emission tomography and its prognostic value in lung cancer
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DOI：
10.1016/s1010-7940(00)00535-2
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发表时间：
2000-10-01
影响因子：
3.4
通讯作者：
Dussek, J
中科院分区：
文献类型：
--
作者：
Dhital, K;Saunders, CAB;Dussek, J
目的：正电子发射断层扫描（PET）越来越多地用作肺癌患者诊断、分期和治疗后评估的准确且非侵入性的检查方法。在这项研究中，我们检查是否摄取[F-18]氟脱氧葡萄糖（FDG），肿瘤细胞中葡萄糖代谢增加的标志物，是原发性肺癌患者的预后价值。研究方法：我们回顾性分析了77例原发性肺癌患者（平均年龄63.0岁;男性/女性比例53：24），这些患者在考虑手术切除前接受全身和局部胸部PET作为诊断和分期程序的一部分。每个原发病灶的FDG标准摄取值（SUV）与肿瘤组织学和患者的临床结果相关。结果：发现SUV ≥ 20具有显著的预后价值。生存的机会各SUV组术后12个月时的（95%置信区间（CI））如下：75.2%（59.6-85.5）SUV < 10; 67.5%（29.0-88.2）; SUV 12-（15）为63.6%（29.7-84.5）; SUV 15-（20）为66.7%（19.5-90.4）; SUV > 20为16.7%（0.01-0.52）。与较低水平的SW相比，SUV为20或更高与风险增加4.66倍相关。我们发现肿瘤组织学与SUV之间没有显着相关性。结论：我们以前曾报道过PET在肺癌患者分期和手术治疗方面的显着优势。本研究进一步支持PET在胸部恶性肿瘤治疗中的额外预后作用，这是由原发病灶摄取的标记FDG量决定的。(C)2000 Elsevier Science B. V.保留所有权利。
Objective: Positron emission tomography (PET) is bring increasingly used as an accurate and non-invasive modality in diagnosis, staging and post-therapy assessment in patients with lungs cancer. In this study, we examine whether the uptake of [F-18] fluorodeoxyglucose (FDG), a marker of increased glucose metabolism in neoplastic cells, is of prognostic value in patients with primary lung cancer. Methods: We have retrospectively analyzed 77 patients (mean age, 63.0 pears; male/female ratio, 53:24) with primary lung cancers who underwent whole body and localized thoracic PET as part of their diagnostic and staging procedures prior to consideration of surgical resection. The standardized uptake value (SUV) of injected FDG for each primary lesion was correlated with tumour histology and the patient's clinical outcome. Results: A SUV of 20 or greater was found to be of significant prognostic value. The chance of survival (with 95% confidence intervals (CI)) at 12 months post-surgery for the various SUV groups was as follows: 75.2% (59.6-85.5) for SUV < 10; 67.5% (29.0-88.2) for SW 10- < 12; 63.6% (29.7-84.5) for SUV 12- ( 15; 66.7% (19.5-90.4) for SUV 15- < 20; 16.7% (0.01-0.52) for SUV > 20. A SUV of 20 or more is associated with a 4.66 times increase in hazard, compared with lower levels of SW. We found no significant correlation between tumour histology and SUV. Conclusion: We have previously reported on the significant advantages of PET in the staging and surgical care of patients with lung cancer. The present study adds further support for an additional prognostic role for PET in the management of thoracic malignancy as determined by the amount of labelled-FDG taken up by the primary lesion. (C) 2000 Elsevier Science B.V. All rights reserved.