VOLUMETRIC MODULATED ARC THERAPY VS. IMRT FOR THE TREATMENT OF DISTAL ESOPHAGEAL CANCER
VOLUMETRIC MODULATED ARC THERAPY VS. IMRT FOR THE TREATMENT OF DISTAL ESOPHAGEAL CANCER
复制标题
DOI：
10.1016/j.meddos.2010.09.009
复制
发表时间：
2011-12-01
影响因子：
1.2
通讯作者：
Podgorsak, Matthew B.
中科院分区：
文献类型：
--
作者：
Van Benthuysen, Liam;Hales, Lee;Podgorsak, Matthew B.
几项研究表明，与调强放射治疗（IMRT）相比，容积调强弧治疗（VMAT）能够减少监测单位和治疗时间。本研究旨在证明VMAT能够为远端食管腺癌提供足够的风险器官（OAR）保留和计划靶体积（PTV）覆盖，同时减少监测单位和治疗时间。计划使用VMAT和IMRT技术治疗14例食管癌患者。根据几个OARS的剂量以及PTV的覆盖范围评价剂量测定质量。通过记录给药所需的监测单位数量评估给药时间。还记录了体V，以评价低剂量辐照的健康组织的体积增加。VMAT和IMRT之间OAR保留的剂量学差异相当。两种技术的PTV覆盖范围相似，但发现IMRT能够提供稍微更均匀的剂量分布。14例患者中，12例采用单弧治疗，2例采用双弧治疗。与调强放射治疗计划相比，单弧计划减少了42%的监测单位。与调强放疗相比，双弧计划减少了67%的监测单位。发现VMAT的身体V比IMRT大18%。VMAT有能力减少IMRT的治疗时间，同时仍然提供类似的OAR保留和PTV覆盖范围。虽然VMAT治疗期间患者移动的风险较小，但这一优势是以向更大体积的患者输送小剂量为代价的。(C)2011年美国医学剂量学家协会。
Several studies have demonstrated that volumetric modulated arc therapy (VMAT) has the ability to reduce monitor units and treatment time when compared with intensity-modulated radiation therapy (IMRT). This study aims to demonstrate that VMAT is able to provide adequate organs at risk (OAR) sparing and planning target volume (PTV) coverage for adenocarcinoma of the distal esophagus while reducing monitor units and treatment time. Fourteen patients having been treated previously for esophageal cancer were planned using both VMAT and IMRT techniques. Dosimetric quality was evaluated based on doses to several OARS, as well as coverage of the PTV. Treatment times were assessed by recording the number of monitor units required for dose delivery. Body V, was also recorded to evaluate the increased volume of healthy tissue irradiated to low doses. Dosimetric differences in OAR sparing between VMAT and IMRT were comparable. PTV coverage was similar for the 2 techniques but it was found that IMRT was capable of delivering a slightly more homogenous dose distribution. Of the 14 patients, 12 were treated with a single arc and 2 were treated with a double arc. Single-arc plans reduced monitor units by 42% when compared with the IMRT plans. Double-arc plans reduced monitor units by 67% when compared with IMRT. The V, for the body was found to be 18% greater for VMAT than for IMRT. VMAT has the capability to decrease treatment times over IMRT while still providing similar OAR sparing and PTV coverage. Although there will be a smaller risk of patient movement during VMAT treatments, this advantage comes at the cost of delivering small doses to a greater volume of the patient. (C) 2011 American Association of Medical Dosimetrists.