Biological effects of new-generation dialkyl phosphinate flame retardants and their hydrolysates in BALB/C mice
Biological effects of new-generation dialkyl phosphinate flame retardants and their hydrolysates in BALB/C mice
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新一代次膦酸二烷基酯阻燃剂及其水解产物对 BALB/C 小鼠的生物学效应。
DOI：
10.1002/tox.22383
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发表时间：
2017-05-01
影响因子：
4.5
通讯作者：
Liang, Yong
中科院分区：
文献类型：
--
作者：
Bao, Jieqing;Liu, Yuchen;Liang, Yong
甲基环己基次膦酸铝 (AMHP)、甲基环己基次膦酸钙 (CMHP)、二乙基次膦酸铝 (ADEP) 和甲基乙基次膦酸铝 (AMEP) 是有机二烷基次膦酸盐 (DP) 和新兴的磷基阻燃剂。广谱DPs阻燃剂占据高端工业市场，但其生态风险却鲜有报道。通过将雄性 BALB/c 小鼠暴露于 DP 和二烷基次膦酸，我们研究了这些化学物质的毒性作用，并测量了血液和粪便中的 AMHP 和甲基环己基次膦酸 (MHPA)。我们发现DPs及其主要水解产物对BALB/c小鼠具有轻度毒性。暴露于 10 和 50 mg/kg/天的 AMEP 和 ADEP 会导致小鼠轻度肝毒性。 CMHP 的毒性存在于肝脏和肾脏。 AMHP及其水解产物MHPA的毒性较低，对肝脏有影响。这些数据表明 AMHP 的毒性低于我们测试的其他 DP。 (c) 2016 年 Wiley periodicals, Inc.Environ Toxicol 32：1578-1586，2017 年。
Aluminum methylcyclohexylphosphinate (AMHP), calcium methylcyclohexylphosphinate (CMHP), aluminum diethylphosphinate (ADEP), and aluminum methylethylphosphinate (AMEP) are organic dialkyl phosphinates (DPs) and emerging phosphorus-based flame retardants. The broad-spectrum DPs flame retardants occupy high-end industrial markets, but their ecologic risk has been reported rarely. By exposing male BALB/c mice to DPs and dialkyl phosphinic acids, we studied the toxic effects of these chemicals, and measured AMHP and methylcyclohexylphosphinic acid (MHPA) in blood and feces. We found that DPs and their main hydrolysates had mild toxicity in BALB/c mice. Exposure to 10 and 50 mg/kg/d of AMEP and ADEP caused mild hepatotoxicity in mice. Toxicity of CMHP was in the liver and kidneys. Toxicity of AMHP and its hydrolysate MHPA was low and affected the liver. These data suggest that AMHP has lower toxicity than the other DPs that we tested. (c) 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1578-1586, 2017.