The role of prelimbic cortex in instrumental conditioning
The role of prelimbic cortex in instrumental conditioning
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DOI：
10.1016/j.bbr.2003.09.023
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发表时间：
2003-11-30
影响因子：
2.7
通讯作者：
Balleine, BW
中科院分区：
文献类型：
--
作者：
Corbit, LH;Balleine, BW
许多研究表明，人类和灵长类动物的前额叶皮层具有在工作记忆中保存和操纵目标或结果相关信息的能力，以指导即将到来的行动的表现。在这里，我们报告了前边缘皮层的细胞体病变损害了大鼠基于先前编码的动作-结果关联选择动作的能力。老鼠被剥夺了食物，并被训练按下两个杠杆，一个提供食物颗粒，另一个提供蔗糖溶液。所有大鼠都获得了杠杆按压反应，但边缘前区大鼠的初始获得速度明显慢于假对照组。此外，在假性损伤大鼠中，训练后使用特定饱腹感程序对两种结果中的一种进行贬值，导致训练中提供首选结果的杠杆上的表现选择性降低，而边缘前大鼠没有表现出选择性贬值效应，似乎非选择性地降低了两种杠杆上的表现。重要的是，这种损伤只在灭绝时出现；在随后的实验中，我们发现，当一个特定的动作-结果关联是通过结果本身的呈现或通过先前与结果配对的刺激来提示时，大鼠表现出选择相关动作的能力。这些结果表明，前边缘大鼠的动作-结果编码可能是完整的，损伤损害了它们在工作记忆中保留这种学习以建立行动过程的能力。或者，病变可能改变了动作-结果和结果-行动关联对乐器演奏的相对贡献。基于此，边缘前病变影响动作-结果编码，但保留结果-动作关联完整，为结果介导的动作启动提供了基础，这可能足以支持受损大鼠的习得和表现。(C) 2003 Elsevier B.V.版权所有
Numerous studies have implicated human and primate prefrontal cortex in the ability to hold and manipulate goal or outcome-related information in working memory to guide the performance of forthcoming actions. Here we report that cell-body lesions of prelimbic cortex impair the ability of rats to select an action based on previously encoded action-outcome associations. Rats were food deprived and trained to press two levers, one delivering food pellets and the other a sucrose solution. All rats acquired the lever-press response although the initial acquisition in the prelimbic rats was significantly slower than in sham controls. Furthermore, whereas in sham-lesioned rats, post-training devaluation of one of the two outcomes using a specific satiety procedure produced a selective reduction in performance on the lever that in training delivered the prefed outcome, prelimbic rats failed to show a-selective devaluation effect and appeared to reduce performance on both levers non-selectively. Importantly, this impairment only emerged in extinction; in subsequent experiments it was found that, when a specific action-outcome association was cued either by presentation of the outcome itself or by presenting a stimulus previously paired with the outcome, rats demonstrated an ability to select the associated action. These results suggest that action-outcome encoding may be intact in prelimbic rats and that the lesion impaired their ability to retain this learning in working memory in order to establish a course of action. Alternatively, the lesion may have altered the relative contribution of action-outcome and outcome-action associations to instrumental performance. On this account, prelimbic lesions affect action-outcome encoding but leave outcome-action associations intact providing the basis for outcome-mediated initiation of an action sufficient, perhaps, to support acquisition and performance in the lesioned rats. (C) 2003 Elsevier B.V. All rights reserved.