Fine functional organization of auditory cortex revealed by Fourier optical imaging
Fine functional organization of auditory cortex revealed by Fourier optical imaging
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DOI：
10.1073/pnas.0505592102
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发表时间：
2005-09-13
影响因子：
11.1
通讯作者：
Stryker, MP
中科院分区：
文献类型：
--
作者：
Kalatsky, VA;Polley, DB;Stryker, MP
我们提供了大鼠听觉皮层功能性音位组织的总体视图。我们应用最近开发的技术来获取大鼠听觉皮层中的内在信号光学图，即傅里叶成像。这些高度详细的图是在长达几分钟的记录过程中得出的，描绘了多个听觉皮层区域并展示了它们的形状、大小和音调顺序。除了初级听觉皮层之外，至少还有三个具有精细音位组织的不同区域，以及至少一个额外的高频场。所有这些皮质区域的排列在不同受试者中是一致的。这些光学图的准确性通过同一受试者的微电极测绘得到证实。这种成像方法可以以与传统微电极技术相当的高空间分辨率快速绘制听觉皮层。尽管尖峰活动在很大程度上负责诱发的内在信号，但光信号的某些特征不能仅用尖峰活动来解释，而可能应归因于其他机制：诱导代谢活动，例如阈下膜现象。
We provide an overall view of the functional tonotopic organization of the auditory cortex in the rat. We apply a recently developed technique for acquiring intrinsic signal optical maps, Fourier imaging, in the rat auditory cortex.,These highly detailed maps, derived in a several-minute-long recording procedure, delineate multiple auditory cortical areas and demonstrate their shapes, sizes, and tonotopic order. Beyond the primary auditory cortex, there are at least three distinct areas with fine-scale tonotopic organization, as well as at least one additional high-frequency field. The arrangement of all of these cortical areas is consistent across subjects. The accuracy of these optical maps was confirmed by microelectrode mapping in the same subjects. This imaging method allows fast mapping of the auditory cortex at high spatial resolution comparable to that provided by conventional microelectrode technique. Although spiking activity is largely responsible for the evoked intrinsic signals, certain features of the optical signal cannot be explained by spiking activity only, and should probably be attributed to other mechanisms: inducing metabolic activity, such as subthreshold membrane phenomena.