Formal synthesis of uvaricin via palladium-mediated double cyclization
Formal synthesis of uvaricin via palladium-mediated double cyclization
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DOI：
10.1021/ol0160304
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发表时间：
2001-06-14
期刊：
影响因子：
5.2
通讯作者：
Jiang, L
中科院分区：
文献类型：
--
作者：
Burke, SD;Jiang, L
[图解]报道了一种新的钯催化、配体控制的双环化反应。通过夏普莱斯不对称双羟化反应将生成的C-2对称二烯去对称化，进而转化为紫草素合成中已知的中间体。
[GRAPHICS]A novel palladium mediated, ligand-controlled double cyclization is reported. The C-2-symmetric diene produced was desymmetrized via Sharpless asymmetric dihydroxylation and was further transformed into a known intermediate in the synthesis of uvaricin.