Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis
Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis
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DOI：
10.1183/09031936.00013006
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发表时间：
2007-09-01
影响因子：
24.3
通讯作者：
Barnes, N. C.
中科院分区：
文献类型：
--
作者：
Gamble, E.;Grootendorst, D. C.;Barnes, N. C.
慢性阻塞性肺疾病（COPD）患者的支气管活检标本显示CD 8 + T淋巴细胞、巨噬细胞数量增加，在一些研究中，中性粒细胞和嗜酸性粒细胞数量增加。戒烟影响COPD患者一秒用力呼气量（FEV 1）下降速率，但对炎症的影响尚不确定。比较目前吸烟者和既往吸烟者COPD患者的支气管活检炎性细胞计数。对来自三项支气管活检研究的上皮下炎性细胞计数数据进行汇总分析，这些研究包括目前吸烟者或既往吸烟者的COPD患者。对来自101名受试者（65名目前吸烟者和36名既往吸烟者）的细胞计数数据进行了以下细胞类型的分析：CD 4+和CD 8 + T淋巴细胞、CD 68+（单核细胞/巨噬细胞）、中性粒细胞弹性蛋白酶+（中性粒细胞）、EG 2+（嗜酸性粒细胞）、肥大细胞类胰蛋白酶+和肿瘤坏死因子-α mRNA阳性细胞。当前吸烟者和既往吸烟者在肺功能方面相似，通过FEV 1（%预测值）、用力肺活量（FVC）和FEV 1/FVC测量。结果表明，吸烟者和前吸烟者之间没有显着差异的任何炎症细胞类型或标记物的数量analysed.It的结论是，在建立慢性阻塞性肺疾病，支气管粘膜炎症细胞浸润是相似的前吸烟者和那些继续吸烟。
Bronchial biopsy specimens from chronic obstructive pulmonary disease (COPD) patients demonstrate increased numbers of CD8+ T-lymphocytes, macrophages and, in some studies, neutrophils and eosinophils. Smoking cessation affects the rate of forced expiratory volume in one second (FEV1) decline in COPD, but the effect on inflammation is uncertain. Bronchial biopsy inflammatory cell counts were compared in current and ex-smokers with COPD.A pooled analysis of subepithelial inflammatory cell count data from three bronchial biopsy studies that included COPD patients who were either current or ex-smokers was performed.Cell count data from 101 subjects, 65 current smokers and 36 ex-smokers, were analysed for the following cell types: CD4+ and CD8+ T-lymphocytes, CD68+ (monocytes/macrophages), neutrophil elastase+ (neutrophils), EG2+ (eosinophils), mast cell tryptase+ and cells mRNA-positive for tumour necrosis factor-alpha. Current smokers and ex-smokers were similar in terms of lung function, as measured by FEV1 (% predicted), forced vital capacity (FVC) and FEV1/FVC. The results demonstrate that there were no significant differences between smokers and ex-smokers in the numbers of any of the inflammatory cell types or markers analysed.It is concluded that, in established chronic obstructive pulmonary disease, the bronchial mucosal inflammatory cell infiltrate is similar in ex-smokers and those that continue to smoke.