Proinflammatory cytokine polymorphisms and the risk of preterm birth and low birthweight in a Japanese population
Proinflammatory cytokine polymorphisms and the risk of preterm birth and low birthweight in a Japanese population
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DOI：
10.1093/molehr/gan078
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发表时间：
2009-02-01
影响因子：
4
通讯作者：
Kishi, R.
中科院分区：
文献类型：
--
作者：
Sata, F.;Toya, S.;Kishi, R.
妊娠和分娩涉及母亲和胎儿之间复杂且知之甚少的分子和生物相互作用。炎症细胞因子已被报道与胎儿生长和分娩。本研究的目的是检查日本人群中常见的促炎细胞因子多态性是否与早产（PTB）、低出生体重或宫内生长受限相关。我们对2001年至2005年期间在日本札幌进行单胎分娩的414名妇女进行了连续系列评估。采用等位基因识别法检测IL 1A-889 C/T、+4845 G/T（A114 S）、IL 1B-511 C/T、-31 C/T、IL 2 - 384 T/G和IL 6 - 634 C/G多态性。携带IL 1A-889 T等位基因的女性PTB风险显著增加（CC基因型[参考]; CT基因型，比值比（OR）：2.5; 95%置信区间（95% CI）：1.4-4.8; CT+TT基因型[显性基因型模型]，OR：2.5，95% CI：1.3-4.6）。同样，携带IL 1A +4845 T等位基因的女性PTB风险显著增加（GG基因型[参考]; GT基因型，OR：2.4，95% CI：1.3-4.4; GT+TT基因型[显性基因型模型]，OR：2.3，95% CI：1.2-4.2）。患PTB的母亲中IL 1A TT单倍型的频率显著高于足月分娩的母亲（P < 0.001），而患PTB的母亲中IL 1A CG单倍型的频率显著低于足月分娩的母亲（P < 0.001）。我们的研究结果表明，在白细胞介素1A基因的多态性和单倍型与PTB在日本妇女。
Pregnancy and parturition involve a complex and poorly understood molecular and biological interplay between mother and fetus. Inflammatory cytokines have been reported to be associated with fetal growth and parturition. The aim of this study was to examine whether common proinflammatory cytokine polymorphisms are associated with preterm birth (PTB), low birthweight or intrauterine growth restriction in a Japanese population. We assessed a consecutive series of 414 women who had singleton deliveries in Sapporo, Japan between 2001 and 2005. Genotyping of IL1A -889C/T, +4845G/T (A114S), IL1B -511C/T, -31C/T, IL2 -384T/G and IL6 -634C/G polymorphisms was determined by an allelic discrimination assay. The risk of PTB significantly increased in women carrying the IL1A -889T allele (CC genotype [reference]; CT genotype, odds ratios (OR): 2.5; 95% confidence intervals (95% CI): 1.4-4.8; CT+TT genotypes [dominant genotype model], OR: 2.5, 95% CI: 1.3-4.6). Similarly, the risk of PTB significantly increased in women carrying the IL1A +4845T allele (GG genotype [reference]; GT genotype, OR: 2.4, 95% CI: 1.3-4.4; GT+TT genotypes [dominant genotype model], OR: 2.3, 95% CI: 1.2-4.2). The frequency of the IL1A TT haplotype in mothers with PTB was significantly higher than in mothers who had a term birth (P < 0.001), whereas the frequency of the IL1A CG haplotype in mothers who had a PTB was significantly lower (P < 0.001). Our findings suggest that the polymorphisms and haplotypes in the IL1A gene are associated with PTB in Japanese women.