An unbalanced monocyte macrophage polarization in the bone marrow microenvironment of patients with poor graft function after allogeneic haematopoietic stem cell transplantation
An unbalanced monocyte macrophage polarization in the bone marrow microenvironment of patients with poor graft function after allogeneic haematopoietic stem cell transplantation
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异基因造血干细胞移植后移植功能不良患者骨髓微环境中单核巨噬细胞极化失衡
DOI：
10.1111/bjh.15452
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发表时间：
2018-09-01
影响因子：
6.5
通讯作者：
Kong, Yuan
中科院分区：
文献类型：
--
作者：
Zhao, Hong-Yan;Lyu, Zhong-Shi;Kong, Yuan
移植功能差（PGF）是同种异体造血干细胞移植（allo-HSCT）的严重并发症。小鼠研究表明，有效的造血依赖于特定的骨髓微环境。越来越多的证据表明，BM巨噬细胞(M？5)是骨髓免疫微环境的重要组成部分，对骨髓造血干细胞（hsc）的调控是不可或缺的。然而，人们对BM的数量和作用知之甚少。或者它们是否直接与PGF患者的hsc相互作用。在目前的前瞻性病例对照研究中，PGF患者的经典活化炎性M？s (M1; 218 +/- 011% vs. 082 +/- 006%， P
Poor graft function (PGF) is a severe complication of allogeneic haematopoietic stem cell transplantation (allo-HSCT). Murine studies have demonstrated that effective haematopoiesis depends on the specific bone marrow (BM) microenvironment. Increasing evidence shows that BM macrophages (M?s), which constitute an important component of BM immune microenvironment, are indispensable for the regulation of haematopoietic stem cells (HSCs) in the BM. However, little is known about the number and function of BM M?s or whether they directly interact with HSCs in PGF patients. In the current prospective case-control study, PGF patients showed a significant increase in classically activated inflammatory M?s (M1; 218 +/- 011% vs. 082 +/- 006%, P